Document Detail


Intracranial Atherosclerosis Is Associated with Progression of Neurological Deficit in Subcortical Stroke.
MedLine Citation:
PMID:  22133907     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Progression of neurological deficit (PND) is a frequent complication of acute subcortical ischemic stroke (SCS). The role of intracranial atherosclerosis (IAS) in PND is controversial. Our goal was to evaluate IAS on admission, as predictor of PND in SCS patients. Methods: SCS patients were identified from our prospective database from 2004 to 2008. Clinical and laboratory data were collected from charts, and radiographic data from original radiographs. The proximal intracranial arteries were graded as patent, irregular, stenotic, or occlusion. IAS was defined as irregularity or stenosis. PND was defined as a change in the National Institutes of Health Stroke Scale >1 point. Results: Two hundred and two SCS patients were identified. In 14%, PND occurred at a median of 2 days from onset. Univariate analysis by infarct location showed the following to be associated with PND: for anterior circulation infarcts (centrum semiovale/basal ganglia), M1 atherosclerosis (p = 0.042); for posterior circulation infarcts, vertebral artery atherosclerosis (p = 0.018). For both groups, we found a non-significant association with age (p = 0.2) and HbA1c levels (p = 0.095). No association was found with admission glucose levels. Multivariate analysis showed the following association with PND: for anterior circulation infarcts, M1 atherosclerosis (OR 4.7; 95% CI 1.2-18.8; p = 0.03); for pontine infarcts, vertebral artery atherosclerosis (OR 5.8; 95% CI 1.1-29.4; p = 0.033). There was an increase in PND likelihood with an increasing number of atherosclerotic vessels. Discussion: In our cohort of SCS patients, PND was associated with IAS of the responsible vessels. These results suggest a role for IAS in the pathogenesis of PNF in SCS patients.
Authors:
Hen Hallevi; Oleg Y Chernyshev; Ramy El Khoury; Michael J Soileau; Kyle C Walker; James C Grotta; Sean I Savitz
Related Documents :
3348817 - 31p-mrs study of bio-energy recovering phenomenon.
10881827 - Free hemoglobin impairs cardiac function in neonatal rabbit hearts.
14726067 - Atrial natriuretic peptide protects against ischemia-reperfusion injury in the isolated...
15240957 - Myocardial and peripheral concentrations of beta-endorphin before and following myocard...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-01
Journal Detail:
Title:  Cerebrovascular diseases (Basel, Switzerland)     Volume:  33     ISSN:  1421-9786     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100851     Medline TA:  Cerebrovasc Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  64-68     Citation Subset:  -    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
Department of Neurology and Stroke Program, Sourasky Medical Center and Tel Aviv University, Tel Aviv, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Symptom severity and attitudes toward medication: Impacts on adherence in outpatients with schizophr...
Next Document:  Meta-analysis of GnRH antagonist protocols: do they reduce the risk of OHSS in PCOS?