| Intracoronary recombinant tissue-type plasminogen activator (rt-PA). | |
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MedLine Citation:
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PMID: 8950493 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intracoronary rt-PA has been used to treat patients with acute myocardial infarction primarily, after failure of intravenous thrombolytic therapy, and when angioplasty has not been technically possible. It has also been used to treat thrombotic closure complicating angioplasty, to treat nonocclusive thrombosis observed during angioplasty, and to pretreat patients with nonacute total occlusions before angioplasty. Intracoronary administration has the potential of providing high local concentrations for a given dose level and may allow lower total doses for the same degree of efficacy. More controlled data are needed on appropriate patient selection, angiographic and clinical endpoints, dose level and regimen, and comparable efficacy of rt-PA and other thrombolytic agents. However, the use of intracoronary rt-PA should be considered when intracoronary thrombus is evident and this route of administration is available. |
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Authors:
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A J Tiefenbrunn |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Coronary artery disease Volume: 7 ISSN: 0954-6928 ISO Abbreviation: Coron. Artery Dis. Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1997-03-05 Completed Date: 1997-03-05 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9011445 Medline TA: Coron Artery Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 637-40 Citation Subset: IM |
Affiliation:
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Washington University School of Medicine, St Louis, Missouri, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary Coronary Angiography Coronary Vessels Dose-Response Relationship, Drug Electrocardiography Humans Infusions, Intra-Arterial Myocardial Infarction / drug therapy*, physiopathology, radiography Plasminogen Activators / therapeutic use* Recombinant Proteins Thrombolytic Therapy / methods* Tissue Plasminogen Activator / therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; EC 3.4.21.-/Plasminogen Activators; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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