Document Detail

Intracoronary recombinant tissue-type plasminogen activator (rt-PA).
MedLine Citation:
PMID:  8950493     Owner:  NLM     Status:  MEDLINE    
Intracoronary rt-PA has been used to treat patients with acute myocardial infarction primarily, after failure of intravenous thrombolytic therapy, and when angioplasty has not been technically possible. It has also been used to treat thrombotic closure complicating angioplasty, to treat nonocclusive thrombosis observed during angioplasty, and to pretreat patients with nonacute total occlusions before angioplasty. Intracoronary administration has the potential of providing high local concentrations for a given dose level and may allow lower total doses for the same degree of efficacy. More controlled data are needed on appropriate patient selection, angiographic and clinical endpoints, dose level and regimen, and comparable efficacy of rt-PA and other thrombolytic agents. However, the use of intracoronary rt-PA should be considered when intracoronary thrombus is evident and this route of administration is available.
A J Tiefenbrunn
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Coronary artery disease     Volume:  7     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-03-05     Completed Date:  1997-03-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  637-40     Citation Subset:  IM    
Washington University School of Medicine, St Louis, Missouri, USA.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary
Coronary Angiography
Coronary Vessels
Dose-Response Relationship, Drug
Infusions, Intra-Arterial
Myocardial Infarction / drug therapy*,  physiopathology,  radiography
Plasminogen Activators / therapeutic use*
Recombinant Proteins
Thrombolytic Therapy / methods*
Tissue Plasminogen Activator / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Recombinant Proteins; EC 3.4.21.-/Plasminogen Activators; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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