Document Detail

Intracoronary pressure and flow velocity for hemodynamic evaluation of coronary stenoses.
MedLine Citation:
PMID:  15030274     Owner:  NLM     Status:  MEDLINE    
Adequate patient selection for percutaneous coronary intervention is of utmost importance to minimize early and late complications. Consequently, objective evidence for myocardial ischemia is mandatory for the management of patients with coronary artery disease, in particular in multivessel disease and intermediate lesions (40-70% diameter stenosis on angiography). The use of sensor-equipped guide wires for the assessment of functional coronary lesion severity has become widespread in the catheterization laboratory. The indices derived from pressure or flow measurements, fractional flow reserve, coronary flow velocity reserve and relative coronary flow velocity reserve show a high agreement with noninvasive stress testing. However, while these indices are based on either intracoronary pressure or flow, they do not investigate the hemodynamics of the coronary circulation entirely, leading to ambiguous outcomes. Only the use of simultaneously measured pressure and flow will avoid any possible misinterpretation of the data.
Martijn Meuwissen; Maria Siebes; Steven A J Chamuleau; Jan G P Tijssen; Jos A E Spaan; Jan J Piek
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of cardiovascular therapy     Volume:  1     ISSN:  1477-9072     ISO Abbreviation:  Expert Rev Cardiovasc Ther     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2004-03-26     Completed Date:  2004-04-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101182328     Medline TA:  Expert Rev Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  471-9     Citation Subset:  IM    
Department of Cardiology, Room B2-250, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
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MeSH Terms
Blood Flow Velocity
Coronary Circulation / physiology*
Coronary Stenosis / diagnosis*,  physiopathology*
Coronary Vessels / physiology*
Laser-Doppler Flowmetry
Severity of Illness Index

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