Document Detail


Intracoronary infusion of catecholamines causes focal arrhythmias in pigs.
MedLine Citation:
PMID:  18479338     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Acute ischemia causes myriad changes including increased catecholamines. We tested the hypothesis that elevated catecholamines alone are arrhythmogenic.
METHODS AND RESULTS: A 504 electrode sock was placed over both ventricles in six open-chest pigs. During control infusion of saline through a catheter in the left anterior descending coronary artery (LAD), no sustained arrhythmias occurred, and the refractory period estimated by the activation recovery interval (ARI) was 175 +/- 14 ms in the LAD bed below the catheter. After infusion of isoproterenol at 0.1 microg/kg/min through the catheter, the ARI in this bed was significantly reduced to 109 +/- 10 ms. A sharp gradient of refractoriness of 43 +/- 10 ms was at the border of the perfused bed. Sustained monomorphic ventricular tachycardia occurred after drug infusion in the perfused bed or near its boundary in all animals with a cycle length of 329 +/- 26 ms and a focal origin. The maximum slope of the ARI restitution curve at the focal origins of the tachyarrhythmias was always <1 (0.62 +/- 0.15). Similar results with a focal arrhythmia origin occurred in two additional pigs in which intramural mapping was performed with 36 plunge needle electrodes in the left ventricular perfused bed.
CONCLUSION: Regional elevation of a catecholamine, which is one of the alterations produced by acute ischemia, can by itself cause tachyarrhythmias. These arrhythmias are closely associated with a shortened refractory period and a large gradient of the spatial distribution of refractoriness but not with a steep restitution curve.
Authors:
Harish Doppalapudi; Qi Jin; Derek J Dosdall; Hao Qin; Gregory P Walcott; Cheryl R Killingsworth; William M Smith; Raymond E Ideker; Jian Huang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-05-09
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  19     ISSN:  1540-8167     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-10     Completed Date:  2009-01-09     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  963-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Catecholamines / administration & dosage*
Female
Infusions, Intra-Arterial
Male
Swine
Ventricular Fibrillation / chemically induced*,  diagnosis,  physiopathology*
Grant Support
ID/Acronym/Agency:
HL-28429/HL/NHLBI NIH HHS; HL-66256/HL/NHLBI NIH HHS; HL-67961/HL/NHLBI NIH HHS; P01 HL067961/HL/NHLBI NIH HHS; P01 HL067961-05/HL/NHLBI NIH HHS; R01 HL028429/HL/NHLBI NIH HHS; R01 HL028429-26/HL/NHLBI NIH HHS; R01 HL066256/HL/NHLBI NIH HHS; R01 HL066256-07/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Catecholamines
Comments/Corrections

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