| Intracoronary infusion of catecholamines causes focal arrhythmias in pigs. | |
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MedLine Citation:
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PMID: 18479338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Acute ischemia causes myriad changes including increased catecholamines. We tested the hypothesis that elevated catecholamines alone are arrhythmogenic. METHODS AND RESULTS: A 504 electrode sock was placed over both ventricles in six open-chest pigs. During control infusion of saline through a catheter in the left anterior descending coronary artery (LAD), no sustained arrhythmias occurred, and the refractory period estimated by the activation recovery interval (ARI) was 175 +/- 14 ms in the LAD bed below the catheter. After infusion of isoproterenol at 0.1 microg/kg/min through the catheter, the ARI in this bed was significantly reduced to 109 +/- 10 ms. A sharp gradient of refractoriness of 43 +/- 10 ms was at the border of the perfused bed. Sustained monomorphic ventricular tachycardia occurred after drug infusion in the perfused bed or near its boundary in all animals with a cycle length of 329 +/- 26 ms and a focal origin. The maximum slope of the ARI restitution curve at the focal origins of the tachyarrhythmias was always <1 (0.62 +/- 0.15). Similar results with a focal arrhythmia origin occurred in two additional pigs in which intramural mapping was performed with 36 plunge needle electrodes in the left ventricular perfused bed. CONCLUSION: Regional elevation of a catecholamine, which is one of the alterations produced by acute ischemia, can by itself cause tachyarrhythmias. These arrhythmias are closely associated with a shortened refractory period and a large gradient of the spatial distribution of refractoriness but not with a steep restitution curve. |
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Authors:
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Harish Doppalapudi; Qi Jin; Derek J Dosdall; Hao Qin; Gregory P Walcott; Cheryl R Killingsworth; William M Smith; Raymond E Ideker; Jian Huang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-05-09 |
Journal Detail:
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Title: Journal of cardiovascular electrophysiology Volume: 19 ISSN: 1540-8167 ISO Abbreviation: J. Cardiovasc. Electrophysiol. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-10-10 Completed Date: 2009-01-09 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9010756 Medline TA: J Cardiovasc Electrophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 963-70 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294-0019, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Catecholamines / administration & dosage* Female Infusions, Intra-Arterial Male Swine Ventricular Fibrillation / chemically induced*, diagnosis, physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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HL-28429/HL/NHLBI NIH HHS; HL-66256/HL/NHLBI NIH HHS; HL-67961/HL/NHLBI NIH HHS; P01 HL067961-05/HL/NHLBI NIH HHS; R01 HL028429-26/HL/NHLBI NIH HHS; R01 HL066256-07/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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