| Intracoronary endothelin-1 increases coronary retrograde pressure by constricting arterioles. | |
| | |
MedLine Citation:
|
PMID: 2097065 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
STUDY OBJECTIVE: The aim was to determine the site of coronary vasoconstriction induced by endothelin, by investigating the response in terms of retrograde pressure and reactive hyperaemia. EXPERIMENTAL MATERIAL: Twelve anaesthetised mongrel dogs, 12-14 kg, were used for the studies. DESIGN: The left anterior descending coronary artery was cannulated and perfused with blood through an extracorporeal bypass. The effects of intracoronary endothelin-1 (1-500 pmol) on coronary blood flow, coronary flow reserve (the peak reactive flow and the repayment after 15 s coronary occlusion), and retrograde coronary pressure during coronary occlusion were studied (n = 7). The retrograde coronary flow was collected from the bypass at each dose (n = 5). MEASUREMENTS AND MAIN RESULTS: At doses of greater than 20 pmol the coronary flow decreased dose dependently and reached almost zero flow at 500 pmol. The coronary flow reserve also decreased; however, the retrograde pressure was raised dose dependently at doses of greater than 10 pmol. At a dose of 500 pmol, the retrograde pressure was increased to 61 mm Hg [82(SEM 12)% of the coronary perfusion pressure]. Retrograde flow remained unchanged throughout the experiment. CONCLUSIONS: The endothelin-1 induced rise in retrograde pressure is in accordance with a dose dependent reduction in coronary flow reserve, and collateral flow was not augmented by endothelin. It is concluded that the effect of endothelin-1 on coronary circulation in situ was mainly due to the constriction of small resistant vessels. |
| | |
Authors:
|
K Fukuda; S Hori; M Kusuhara; T Satoh; S Kyotani; S Inoue; H Ohno; K Yamaguchi; S Handa; Y Nakamura |
Related Documents
:
|
8173535 - Effects of aluminum on the mechanical and electrical activity of the langendorff-perfus... 6992235 - Comparison in anesthetized dogs of the anti-aggregatory and hemodynamic effects of pros... 1735165 - In vivo relation of intramyocardial blood volume to myocardial perfusion. evidence supp... 6723695 - Leukotriene d4-induced vasoconstriction of coronary arteries in anaesthetized dogs. 20349155 - A randomized community-based intervention trial comparing faith community nurse referra... 12164255 - A novel method for chronic measurement of respiratory function in the conscious monkey. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Cardiovascular research Volume: 24 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1990 Dec |
Date Detail:
|
Created Date: 1991-07-22 Completed Date: 1991-07-22 Revised Date: 2010-03-24 |
Medline Journal Info:
|
Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 987-92 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Keio University School of Medicine, Tokyo, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects Coronary Circulation / drug effects Coronary Vessels / drug effects* Dogs Dose-Response Relationship, Drug Endothelins / pharmacology* Vasoconstriction / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Endothelins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Myocardial pathology in rats exposed to prolonged environmental heat.
Next Document: Protective effects of calcium channel blockers on hydrogen peroxide induced increases in endothelial...