Document Detail


Intracoronary bivalirudin for no reflow reversal: a second chance to treat this disorder?
MedLine Citation:
PMID:  18597045     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
No reflow, defined as failure to restore normal myocardial blood flow despite removal of coronary obstruction, is a not rare complication of ST-elevation acute myocardial infarction. We here describe the case of an old patient experiencing inferior and right ventricle myocardial infarction complicated by cardiogenic shock, anaemia and thrombocytopenia. We managed it with urgent PCI using thrombus aspirator, that determined onset of no reflow, that we successfully managed with intracoronary bivalirudin. We showed how bivalirudin, a drug whose use is increasing in the catheterization laboratories, could be safely used via the intracoronary route to treat no reflow phenomenon due to distal microembolization in a complex patient.
Authors:
Bernardo Cortese; Andrea Picchi; Andrea Micheli; Ugo Limbruno
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-07-03
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  28     ISSN:  1573-742X     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-10     Completed Date:  2009-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  74-6     Citation Subset:  IM    
Affiliation:
Interventional Cardiology, Ospedale della Misericordia, Grosseto, Italy. bcortese@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Aged, 80 and over
Anticoagulants / administration & dosage*
Coronary Circulation / drug effects*
Heart Catheterization*
Hirudins / administration & dosage*
Humans
Myocardial Infarction / radiography,  therapy*
Peptide Fragments / administration & dosage*
Recombinant Proteins / administration & dosage
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Hirudins; 0/Peptide Fragments; 0/Recombinant Proteins; 128270-60-0/bivalirudin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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