Document Detail

Intracoronary beta-irradiation enhances balloon-injury-induced tissue factor expression in the porcine injury model.
MedLine Citation:
PMID:  15204169     Owner:  NLM     Status:  MEDLINE    
Intracoronary brachytherapy (ICBT) effectively reduces restenosis but is associated with late thrombosis. Since tissue factor (TF) is an important mediator of arterial thrombosis, we tested the hypothesis that ICBT results in persistently augmented TF expression. Coronary arteries from 12 pigs were randomized to: control (C; no injury), oversized balloon injury (BI), or BI followed by ICBT. Animals were sacrificed at 1, 7, 14, or 60 days postprocedure, and coronary arteries collected for expression analyses and immunostaining. ICBT-treated arteries had higher TF antigen and activity at all time-points compared to BI arteries (Western blot: 16 571 +/- 2090 vs 10 135 +/- 2939 densitometric units, p = 0.001; ELISA: 0.42 +/- 0.13 nM vs 0.25 +/- 0.14 nM, p = 0.001; TF activity assay: 0.303 +/- 0.11 nM vs 0.18 +/- 0.07 nM, p = 0.01; immunohistochemical staining: 30.6 +/- 6.6% vs 11.5% +/- 3.2%, p = 0.01). TF expression increased following BI, increased further following ICBT, and persisted for the duration of the study. We conclude that TF expression increases after BI, but is further increased and persists for a longer duration following ICBT, suggesting that a TF-mediated mechanism may play a role in late thrombosis following ICBT.
Ariel Finkelstein; Joerg Hausleiter; Terence Doherty; Kaname Takizawa; Jonathan Bergman; Ming Liu; Vladimir Rukshin; Michael Fishbein; Neal Eigler; Prediman Shah; Tripathi Rajavashisth; Raj Makkar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of cardiovascular interventions     Volume:  6     ISSN:  1462-8848     ISO Abbreviation:  Int J Cardiovasc Intervent     Publication Date:  2004  
Date Detail:
Created Date:  2004-06-18     Completed Date:  2004-07-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9815622     Medline TA:  Int J Cardiovasc Intervent     Country:  England    
Other Details:
Languages:  eng     Pagination:  20-7     Citation Subset:  IM    
The Cardiovascular Intervention Research Center, Cedars-Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
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MeSH Terms
Balloon Dilatation / adverse effects*
Blotting, Western
Brachytherapy / methods*
Coronary Restenosis / etiology
Coronary Thrombosis / etiology
Coronary Vessels / injuries*,  radiation effects*
Enzyme-Linked Immunosorbent Assay
Thromboplastin / metabolism*
Grant Support
Reg. No./Substance:

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