| Intracoronary autologous bone marrow-derived mononuclear cell transplantation improves coronary collateral vessel formation and recruitment capacity in patients with ischemic cardiomyopathy: a combined hemodynamic and scintigraphic approach. | |
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MedLine Citation:
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PMID: 18403459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigated the effects of intracoronary autologous bone marrow-derived mononuclear cell (BMC) transplantation on coronary microcirculation. Fifteen patients with ischemic cardiomyopathy were treated by intracoronary infusion of BMCs via the patent infarct-related artery. The thermodilution-derived coronary flow reserve, index of microvascular resistance, pressure-derived collateral flow index, and coronary wedge pressure were measured at baseline and at 6 months. Successive balloon inflations during BMC transplantation were performed to observe the recruitment in pressure-derived collateral flow index and coronary wedge pressure, and the percentage changes between baseline and 6 months were calculated. The mean (SD) coronary flow reserve increased from 1.3 (0.4) to 2.1 (0.5), and the mean (SD) index of microvascular resistance decreased from 44.9 (24.4) to 21.2 (14.1) (P = .001 for both). The mean (SD) improvement in pressure-derived collateral flow index (from 0.14 [0.05] to 0.22 [0.08]) was also statistically significant (P = .001). Similarly, the percentage improvements in pressure-derived collateral flow index and coronary wedge pressure were statistically significant (P = .01 for both). The percentage improvement in perfusion assessed by single-photon emission computed tomography strongly correlated with the percentage changes in pressure-derived collateral flow index (r = 0.88, P = .001) and coronary wedge pressure (r = 0.69, P = .01). These results demonstrate for the first time (to our knowledge) that intracoronary autologous BMC transplantation improves coronary collateral vessel formation and recruitment capacity in human subjects. |
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Authors:
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Yelda Tayyareci; Murat Sezer; Berrin Umman; Sevgi Besisik; Ayse Mudun; Yasemin Sanli; Aytac Oncul; Nuray Gurses; Deniz Sargin; Mehmet Meric; Yilmaz Nisanci |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Angiology Volume: 59 ISSN: 0003-3197 ISO Abbreviation: Angiology Publication Date: 2008 Apr-May |
Date Detail:
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Created Date: 2008-04-11 Completed Date: 2008-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: United States |
Other Details:
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Languages: eng Pagination: 145-55 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University of Istanbul, Turkey. yeldatayyareci@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure Bone Marrow Transplantation* Cardiomyopathies / complications, radionuclide imaging, surgery* Collateral Circulation* Coronary Circulation* Coronary Vessels / radionuclide imaging Female Humans Male Middle Aged Myocardial Ischemia / complications, radionuclide imaging, surgery* Prospective Studies Stroke Volume Tomography, Emission-Computed, Single-Photon Transplantation, Autologous |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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