Document Detail

Intracoronary PGE2 and veratrine inhibits renin release in conscious dogs via chemosensitive ventricular afferents.
MedLine Citation:
PMID:  1395108     Owner:  NLM     Status:  MEDLINE    
1. Prostaglandins (PG) and veratrum alkaloids stimulate ventricular sensory receptors with non-myelinated vagal afferents and mediate inhibitory circulatory responses. 2. The present study in conscious instrumented dogs was carried out to determine the effects of intracoronary artery infusions of veratrine (Ver-IC) and PGE2 (PGE2-IC) on plasma renin activity (PRA). 3. A 15-20 mmHg decrease in arterial pressure was produced during Ver-IC (0.2-0.8 micrograms/kg per min) and PGE2-IC (10-50 ng/kg per min), but there was no change in PRA or heart rate. 4. In contrast, significant increases in PRA (+3.51 +/- 0.37 ng angiotensin I/mL per h; P less than 0.01) and heart rate (+38.5 +/- 6.2 beats/min; P less than 0.001) were elicited in response to a 15-20 mmHg decrease in arterial pressure produced by intravenous infusions of nitroprusside. 5. Pharmacological blockade of afferent fibres in the pericoronary region of the left main coronary artery during Ver-IC resulted in significant hypotension-induced increases in PRA (P less than 0.001) and heart rate (P less than 0.001), thus removing the inhibitory influence of chemosensitive ventricular afferents. 6. Therefore, intracoronary veratrum alkaloids and prostaglandins inhibit hypotension-induced increases in PRA and heart rate in the conscious dog. This is mediated by chemosensitive receptors located in the left ventricular myocardium along with afferent nerves in the pericoronary region and cervical vagi.
A J Gorman; J S Chen; S Foster; R G Snyder; S G Iams
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  19     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-11-06     Completed Date:  1992-11-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  645-55     Citation Subset:  IM    
Department of Biological Research, Hoechst-Roussel Pharmaceuticals Inc., Somerville, New Jersey 08876.
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MeSH Terms
Blood Pressure / drug effects
Coronary Vessels
Dinoprostone / administration & dosage,  pharmacology*
Heart Rate / drug effects
Heart Ventricles / innervation*
Infusions, Intra-Arterial
Nerve Block
Neurons, Afferent / drug effects,  physiology*
Nitroprusside / pharmacology
Renin / blood*
Sensory Receptor Cells / drug effects*,  physiology
Veratrine / pharmacology*
Reg. No./Substance:
15078-28-1/Nitroprusside; 363-24-6/Dinoprostone; 62-59-9/Veratrine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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