Document Detail

Intracervical versus intravaginal PGE2 for induction of labor at term in patients with an unfavorable cervix.
MedLine Citation:
PMID:  3861138     Owner:  NLM     Status:  MEDLINE    
In a randomized double-blind study we evaluated the effects on cervical ripening and labor induction of 0.5 mg PGE2 in gel given intracervically and 2.0 mg PGE2 given as a vaginal suppository. All patients were at term with unfavorable cervical scores. The indications for induction were toxemia, diabetes mellitus, Rh-immunization, or intrauterine growth retardation. Significantly better results for both cervical priming and labor induction were obtained after intracervical PGE2-gel application than after treatment with placebo or vaginal suppositories. Eleven out of 19 patients (58%) were delivered within 24 h after intracervical PGE2-gel compared to two out of 19 patients given placebo (p less than 0.01). In patients not delivered 24 h after the start of treatment, the mean cervical score had changed from 3.7 to 6.0 (p less than 0.05) after PGE2-gel application compared to a change from 3.9 to 4.3 after placebo treatment (n.s.). The outcome after treatment with PGE2 suppositories did not differ significantly from that with placebo treatment. In a subsequent study 25 patients were given 0.5 mg PGE2-gel intracervically. The results were consistent with those obtained in patients receiving PGE2-gel intracervically in the double-blind study. Few side effects were noted. No patient complained of gastro-intestinal discomfort but increased myometrial activity was observed in two patients; one after placebo and the other after active intracervical PGE2-gel treatment. The hyperactivity was readily countered with the beta 2-agonist, terbutaline. All infants were born in good condition with Apgar scores of 7 or more within 5 min. At pediatric examinations at 1 week and at 6 months of age all children seemed healthy.
U Ulmsten; G Ekman; P Belfrage; M Bygdeman; C Nyberg
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of gynecology     Volume:  236     ISSN:  0170-9925     ISO Abbreviation:  Arch. Gynecol.     Publication Date:  1985  
Date Detail:
Created Date:  1985-09-04     Completed Date:  1985-09-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7901051     Medline TA:  Arch Gynecol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  243-8     Citation Subset:  IM    
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MeSH Terms
Administration, Topical
Cervix Uteri / drug effects*
Cesarean Section
Double-Blind Method
Labor, Induced*
Prostaglandins E* / administration & dosage
Prostaglandins E, Synthetic* / administration & dosage
Random Allocation
Time Factors
Reg. No./Substance:
0/Gels; 0/Prostaglandins E; 0/Prostaglandins E, Synthetic; 0/Suppositories; 363-24-6/Dinoprostone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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