Document Detail

Intracervical fibrin sealants: a potential treatment for early preterm premature rupture of the membranes.
MedLine Citation:
PMID:  11228489     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We report our experience with a transvaginally applied intracervical fibrin sealant at <24 weeks' gestation. STUDY DESIGN: This is an observational study of a referred patient population, with preterm premature rupture of the membranes at <24 weeks' gestation. RESULTS: Twelve women consented to our protocol. The mean gestational age at preterm premature rupture of membranes was 19 weeks 4 days (range, 13-23 weeks); the mean gestational age at treatment was 20 weeks 5 days (range, 17-23 weeks). All women had a diminution in the amount of amniotic fluid leakage with an increase in amniotic fluid index. Among the 12 pregnancies (13 fetuses), there were 7 surviving neonates. Two women had apparent "resealing" of the membranes. CONCLUSION: Fibrin sealants in midtrimester rupture of the membranes may lead to improved outcomes and now warrant formal evaluation.
A C Sciscione; J S Manley; M Pollock; B Maas; P A Shlossman; W Mulla; M Lankiewicz; G H Colmorgen
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  184     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-03-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  368-73     Citation Subset:  AIM; IM    
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Christiana Care Health Services, Newark, Delaware 19718, USA.
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MeSH Terms
Amniotic Fluid / physiology,  ultrasonography
Bed Rest
Cervix Uteri / pathology
Fetal Membranes, Premature Rupture / complications,  therapy*
Fibrin Tissue Adhesive / administration & dosage,  therapeutic use*
Gestational Age
Oligohydramnios / complications
Pilot Projects
Pregnancy Outcome
Reg. No./Substance:
0/Fibrin Tissue Adhesive

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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