Document Detail

Intracerebroventricular vasopressin reduces CSF absorption rate in the conscious goat.
MedLine Citation:
PMID:  1855557     Owner:  NLM     Status:  MEDLINE    
Cerebrospinal fluid (CSF) levels of vasopressin (AVP) are elevated in some disorders associated with raised intracranial pressure. We have previously demonstrated that intracerebroventricular infusion of AVP in the conscious goat leads to elevation of intracranial pressure by a mechanism independent of changes in arterial blood pressure or circulating neurohypophysial peptide concentrations. We have now examined the effect of increasing CSF AVP levels on CSF dynamics using the technique of ventriculo-cisternal perfusion in the conscious goat. Intracerebroventricular perfusion with 5 pmol/min AVP in artificial CSF did not alter CSF formation rate but significantly reduced CSF absorption rate (24% decrease; p less than 0.01), when compared with perfusion using artificial CSF alone. This AVP-mediated reduction in CSF absorption rate may represent increased resistance to resorption of CSF or may reflect the effect of raised intracranial pressure.
J R Seckl; S L Lightman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental brain research     Volume:  84     ISSN:  0014-4819     ISO Abbreviation:  Exp Brain Res     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-29     Completed Date:  1991-08-29     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0043312     Medline TA:  Exp Brain Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  173-6     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Arginine Vasopressin / administration & dosage,  blood,  pharmacology*
Blood Pressure / drug effects
Cerebral Ventricles / drug effects,  physiology*
Cerebrospinal Fluid / drug effects,  physiology*
Infusions, Parenteral
Intracranial Pressure / drug effects
Reg. No./Substance:
113-79-1/Arginine Vasopressin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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