Document Detail


Intracerebroventricular serotonin reduces the degree of acute hypoxic ventilatory depression in peripherally chemodenervated rabbits.
MedLine Citation:
PMID:  18935908     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypoxia causes changes in the rate of synthesis or release of neurotransmitters in the brain. The accumulation of serotonin (5-HT) in the central nervous system might cause hypoxic respiratory depression. In the present study, we aimed to examine the role of central 5-HT on normoxic and acute hypoxic ventilatory depression (AHVD) in peripheral chemoreceptors denervated rabbits. All experiments were performed in peripherally chemodenervated rabbits anesthetized with intravenous injection of urethane (400 mg/kg) and alpha-chloralose (40 mg/kg). For intracerebroventricular (ICV) administration of 5-HT (20 microg/kg) and ketanserin (10 microg/kg), a cannula was placed in left lateral ventricle by stereotaxic method. Respiratory frequency (fR), tidal volume (VT), ventilation minute volume (VE) and systemic arterial bood pressure (BP) were recorded in each experimental phases and mean arterial pressure was calculated (MAP). Heart rate (HR) was also determined from the pulsation of BP. The effects of ICV serotonin and ICV ketanserin on the indicated parameters during air breathing (normoxia) and breathing of hypoxia (8% O2--92% N2) were investigated. During hypoxia, fR, VT, VE, MAP and HR decreased, and AHVD was thus obtained. ICV injection of 5-HT during normoxia caused significant increases in VT (P < 0.001) and in VE (P < 0.01). On the other hand, ICV 5-HT injection reduced the degree of AHVD in peripherally chemodenervated rabbits during hypoxia (fR; P < 0.05, VT; P < 0.05 and VE; P < 0.01). After ICV injection of ketanserin, the enhancement of 5-HT on VE was prevented during normoxia. On the breathing of hypoxic gas after ICV ketanserin, the degree of AHVD was augmented. In conclusion, our findings suggested that central 5-HT increases normoxic ventilation and reduces the degree of AHVD during hypoxia and that ICV ketanserin prevents the stimulatory effect of 5-HT on respiration and augments AHVD.
Authors:
Ibrahim Guner; Gulderen Sahin; Nermin Karaturan Yelmen; Ugur Aksu; Tulin Oruc; Zeynep Yildirim
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Chinese journal of physiology     Volume:  51     ISSN:  0304-4920     ISO Abbreviation:  Chin J Physiol     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-10-21     Completed Date:  2008-11-25     Revised Date:  2009-08-12    
Medline Journal Info:
Nlm Unique ID:  7804502     Medline TA:  Chin J Physiol     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  136-45     Citation Subset:  IM    
Affiliation:
Istanbul University, Cerrahpasa Faculty of Medicine, Department of Physiology, Istanbul, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Anoxia / physiopathology*
Carbon Dioxide / metabolism
Chloralose
Hydrogen-Ion Concentration
Injections, Intraventricular
Ketanserin / pharmacology
Oxygen / metabolism
Rabbits
Receptors, Serotonin, 5-HT1 / drug effects
Receptors, Serotonin, 5-HT2 / drug effects
Respiration / drug effects*
Respiratory Insufficiency / metabolism,  physiopathology*,  prevention & control*
Serotonin / administration & dosage,  pharmacology*
Serotonin Agents / administration & dosage,  pharmacology*
Serotonin Antagonists / pharmacology
Sympathectomy, Chemical*
Urethane
Chemical
Reg. No./Substance:
0/Receptors, Serotonin, 5-HT1; 0/Receptors, Serotonin, 5-HT2; 0/Serotonin Agents; 0/Serotonin Antagonists; 124-38-9/Carbon Dioxide; 15879-93-3/Chloralose; 50-67-9/Serotonin; 51-79-6/Urethane; 74050-98-9/Ketanserin; 7782-44-7/Oxygen
Comments/Corrections
Erratum In:
Chin J Physiol. 2008 Aug 31;51(4):261

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