Document Detail

Intracerebroventricular injection of kynurenic acid attenuates corticotrophin-releasing hormone-augmented stress responses in neonatal chicks.
MedLine Citation:
PMID:  22732505     Owner:  NLM     Status:  Publisher    
In the brain of neonatal chicks, tryptophan has a sedative effect, and a part of this effect might be dependent upon its metabolite, serotonin. However, the functional mechanisms have not been fully clarified, since L-tryptophan produces kynurenic acid through the kynurenine pathway. The present study aimed to clarify the effect of kynurenic acid on the stress response upon social isolation. Intracerebroventricular injection of kynurenic acid induced a strong sedative effect under stress compared with the effect of L-tryptophan, with or without intracerebroventricular injection of corticotrophin-releasing hormone (CRH). Kynurenic acid dose-dependently induced sedative and hypnotic effects under CRH-augmented social isolation stress. Taken together, these results indicate that kynurenic acid is a likely candidate for the sedative and hypnotic effects of tryptophan under acutely stressful conditions.
Junki Yoshida; Shozo Tomonaga; Yumi Ogino; Mao Nagasawa; Koji Kurata; Mitsuhiro Furuse
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-22
Journal Detail:
Title:  Neuroscience     Volume:  -     ISSN:  1873-7544     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Laboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
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