Document Detail


Intracerebroventricular infusions of corticotrophin releasing factor (CRF) and ACTH raise blood pressure in sheep.
MedLine Citation:
PMID:  6097379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infusion of synthetic ovine CRF (10 or 100 micrograms/h) into the lateral lateral cerebral ventricle for 24 h increased mean arterial blood pressure of conscious sheep. CRF infusion also increased urine output and sodium excretion. Intravenous infusion of CRF (100 micrograms/h) or intraventricular infusion of artificial CSF had no effect on blood pressure. Intraventricular infusion of ACTH (1-24) at 0.5 micrograms/kg per day, a rate of infusion which has no systemic effect on blood pressure, also raised mean arterial pressure. These studies suggest that two peptides involved in the physiological response to 'stress' may influence blood pressure by mechanisms which do not involve stimulation of adrenocortical steroid production.
Authors:
B A Scoggins; J P Coghlan; D A Denton; D W Fei; M A Nelson; G W Tregear; J Tresham; X M Wang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  11     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:    1984 Jul-Aug
Date Detail:
Created Date:  1985-03-07     Completed Date:  1985-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  365-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / administration & dosage,  pharmacology*
Animals
Blood Pressure / drug effects*
Brain / drug effects*
Corticotropin-Releasing Hormone / administration & dosage,  pharmacology*
Injections, Intraventricular
Sheep
Chemical
Reg. No./Substance:
9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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