Document Detail

Intracerebroventricular capsaicin influences the body weight increasing of rats.
MedLine Citation:
PMID:  18687387     Owner:  NLM     Status:  In-Process    
Adult rats were treated for ten days with capsaicin or with NaCl 0.9% directly injected into the lateral cerebral ventricles through a surgically implanted cannula. A third group of rats was implanted with the same cannula but did not receive any treatment. The food intake and the body weight were recorded for at least six weeks after stopping the treatment. The animals were always kept at constant ambient temperature of 22 °C. The body weight of the capsaicin-treated group was reduced by the treatment, and showed a regular but lower degree of recovery trend than the control groups after the treatment period. In fact the capsaicin treated animals never reached the body weight of the controls. Nevertheless, food intake did not significantly vary after the capsaicin treatment. On the basis of these and previous findings, we can assume that capsaicin injected into the cerebral ventricles to rats kept at constant ambient temperature can acts on hypothalamic neurons, but a permanent action on metabolic pathways can not be excluded.
M Falchi; A Bertelli; F Ferrara; R Galazzo; S Galazzo; C Gharib; B Dib
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Publication Detail:
Type:  Journal Article     Date:  2008-08-05
Journal Detail:
Title:  Brain research bulletin     Volume:  77     ISSN:  1873-2747     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2010-10-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  253-6     Citation Subset:  IM    
Department of Pharmacology, University of Milan, Milan, Italy.
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