| Intracerebroventricular administration of urotensin II regulates food intake and sympathetic nerve activity in brown adipose tissue. | |
| | |
MedLine Citation:
|
PMID: 22426154 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
To clarify the functional roles of urotensin II in regulating energy balance, we investigated the effects of a central infusion of urotensin II on food intake, uncoupling protein (UCP) 1 mRNA expression, temperature, and sympathetic nervous system activity in brown adipose tissue (BAT), a site that regulates energy expenditure in rodents. A bolus central infusion of urotensin II at a dose of 1nmol/rat into the third cerebral ventricle decreased food intake (p<0.05). Additionally, urotensin II induced c-Fos-like-immunoreactivity (c-FLI) in the paraventricular nucleus (PVN) as compared with that in the control (phosphate buffered saline [PBS]-treated) group. Furthermore, urotensin II increased BAT UCP 1 mRNA expression (p<0.05). Finally, central infusion of urotensin II significantly increased BAT sympathetic nerve activity, which was accompanied by a significant elevation in BAT temperature (p<0.05) in rats. Taken together, central infusion of urotensin II regulates food intake and BAT sympathetic nerve activity in rats. |
| | |
Authors:
|
Tohru Yasuda; Takayuki Masaki; Koro Gotoh; Seiichi Chiba; Tetsuya Kakuma; Hironobu Yoshimatsu |
Related Documents
:
|
17179564 - Postweaning growth check in pigs is markedly reduced by intermittent suckling and exten... 17629684 - "feeding time" for the brain: a matter of clocks. 19009044 - Effects of food type, feeding frequency, and temperature on juvenile survival and growt... 7265904 - Feed consumption and food passage time in mink (mustela vison) and european ferrets (mu... 15378994 - Pesticides in mountain yellow-legged frogs (rana muscosa) from the sierra nevada mounta... 10179334 - Medical device reporting: manufacturer reporting, importer reporting, user facility rep... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-3-10 |
Journal Detail:
|
Title: Peptides Volume: - ISSN: 1873-5169 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-3-19 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8008690 Medline TA: Peptides Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
|
Department of Internal Medicine I, Faculty of Medicine, Oita University, 1-1, Idaigaoka, Hasama, Oita 879-5593, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Toxicity assay in repeated doses of Dermatophagoides siboney allergen extract in mice.
Next Document: Developmental changes in renal function.