Document Detail

Intracerebroventricular administration of urotensin II regulates food intake and sympathetic nerve activity in brown adipose tissue.
MedLine Citation:
PMID:  22426154     Owner:  NLM     Status:  Publisher    
To clarify the functional roles of urotensin II in regulating energy balance, we investigated the effects of a central infusion of urotensin II on food intake, uncoupling protein (UCP) 1 mRNA expression, temperature, and sympathetic nervous system activity in brown adipose tissue (BAT), a site that regulates energy expenditure in rodents. A bolus central infusion of urotensin II at a dose of 1nmol/rat into the third cerebral ventricle decreased food intake (p<0.05). Additionally, urotensin II induced c-Fos-like-immunoreactivity (c-FLI) in the paraventricular nucleus (PVN) as compared with that in the control (phosphate buffered saline [PBS]-treated) group. Furthermore, urotensin II increased BAT UCP 1 mRNA expression (p<0.05). Finally, central infusion of urotensin II significantly increased BAT sympathetic nerve activity, which was accompanied by a significant elevation in BAT temperature (p<0.05) in rats. Taken together, central infusion of urotensin II regulates food intake and BAT sympathetic nerve activity in rats.
Tohru Yasuda; Takayuki Masaki; Koro Gotoh; Seiichi Chiba; Tetsuya Kakuma; Hironobu Yoshimatsu
Related Documents :
17179564 - Postweaning growth check in pigs is markedly reduced by intermittent suckling and exten...
17629684 - "feeding time" for the brain: a matter of clocks.
19009044 - Effects of food type, feeding frequency, and temperature on juvenile survival and growt...
7265904 - Feed consumption and food passage time in mink (mustela vison) and european ferrets (mu...
23799334 - Treatment of food anaphylaxis with traditional chinese herbal remedies: from mouse mode...
15378994 - Pesticides in mountain yellow-legged frogs (rana muscosa) from the sierra nevada mounta...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-10
Journal Detail:
Title:  Peptides     Volume:  -     ISSN:  1873-5169     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Department of Internal Medicine I, Faculty of Medicine, Oita University, 1-1, Idaigaoka, Hasama, Oita 879-5593, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Toxicity assay in repeated doses of Dermatophagoides siboney allergen extract in mice.
Next Document:  Developmental changes in renal function.