Document Detail

Intracerebroventricular acute and chronic administration of obestatin minimally affect food intake but not weight gain in the rat.
MedLine Citation:
PMID:  17259788     Owner:  NLM     Status:  MEDLINE    
We studied the effect of the acute central administration of obestatin on food intake and body weight in short-term starved male rats, and those of 28-day continuous intracerebroventricular (icv) infusion of obestatin in free feeding rats. In 16-h starved rats, obestatin induced a trend toward a reduction of food intake that did not reach statistical significance. In fed rats, the icv infusion of obestatin significantly decreased food consumption in the first day of treatment; but the anorexigenic effect of obestatin vanished thereafter. Interestingly, the body weight of rats infused for 28 days with obestatin was superimposable to that of the respective control at all time intervals. In all, our results indicate that the anorexigenic effect of obestatin is of little account and that the peptide does not modify energy metabolism in the long-term administration.
V Sibilia; E Bresciani; N Lattuada; D Rapetti; V Locatelli; V De Luca; F Donà; C Netti; A Torsello; F Guidobono
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  29     ISSN:  1720-8386     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-01-29     Completed Date:  2007-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  RC31-4     Citation Subset:  IM    
Department of Pharmacology, Chemoterapy, and Medical Toxicology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy.
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MeSH Terms
Body Weight / drug effects*
Cerebral Ventricles
Eating / drug effects*
Infusions, Parenteral
Injections, Intraventricular
Peptide Hormones / administration & dosage,  pharmacology*
Rats, Sprague-Dawley
Reg. No./Substance:
0/Peptide Hormones; 0/obestatin, rat

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