Document Detail


Intracerebroventricular 2-DG causes feeding in the absence of other signs of glucoprivation.
MedLine Citation:
PMID:  7427740     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intracerebroventricular (ICV) infusions of 2-deoxy-D-glucose (2-DG) elicited hyperglycemia and increased feeding at short latencies. If access to food was prevented for 6 h post-2-DG infusion, when blood glucose levels were normal and brain 2-DG concentrations were virtually zero, the rats still ate significantly more food than they did 6 h after control infusions. These data indicate that activation of brain glucoreceptors may mediate increased feeding even after other signs of cerebral glucoprivation have disappeared.
Authors:
R M Engeset; R C Ritter
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  202     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-01-16     Completed Date:  1981-01-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  229-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / metabolism
Deoxy Sugars / pharmacology*
Deoxyglucose / pharmacology*
Eating / drug effects*
Injections, Intraventricular
Male
Rats
Grant Support
ID/Acronym/Agency:
5 R01 AM20035/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Deoxy Sugars; 154-17-6/Deoxyglucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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