Document Detail

Intracerebral varicella-zoster virus reactivation in congenital varicella syndrome.
MedLine Citation:
PMID:  14667077     Owner:  NLM     Status:  MEDLINE    
Patients with congenital varicella syndrome (CVS) typically present with clinical symptoms consisting of skin lesions, neurological defects, eye diseases, and/or limb hypoplasia. In rare cases, isolated manifestations in the brain or eye have been reported. The varicella-zoster virus (VZV), as the causative agent of CVS, could only be detected in a few infants with CVS. In addition, there is little in the literature on antiviral treatment of infants born with signs of CVS. We report a case of CVS in a male infant who presented with generalized clonic cerebral seizures at age 4 months. An endogenous intracerebral viral reactivation following intrauterine VZV infection was assumed. After the diagnosis was confirmed virologically, acyclovir was administered intravenously for 10 days and afterwards orally for 3 weeks. This antiviral treatment was aimed at preventing progression of the disease. We concluded from this case that infants with intrauterine VZV infection can suffer intracerebral VZV reactivations that require antiviral treatment.
A Sauerbrei; J Pawlak; C Luger; P Wutzler
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  45     ISSN:  0012-1622     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-11     Completed Date:  2004-01-09     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  837-40     Citation Subset:  IM    
Institute of Virology and Antiviral Therapy, Friedrich-Schiller University of Jena, Germany.
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MeSH Terms
Central Nervous System Diseases / drug therapy,  physiopathology,  virology
Chickenpox / diagnosis,  drug therapy,  physiopathology*,  virology
Follow-Up Studies
Herpesvirus 3, Human*
Magnetic Resonance Imaging
Polymerase Chain Reaction / methods
Pregnancy Complications, Infectious / etiology*,  virology

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