Document Detail


Intracerebral varicella-zoster virus reactivation in congenital varicella syndrome.
MedLine Citation:
PMID:  14667077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with congenital varicella syndrome (CVS) typically present with clinical symptoms consisting of skin lesions, neurological defects, eye diseases, and/or limb hypoplasia. In rare cases, isolated manifestations in the brain or eye have been reported. The varicella-zoster virus (VZV), as the causative agent of CVS, could only be detected in a few infants with CVS. In addition, there is little in the literature on antiviral treatment of infants born with signs of CVS. We report a case of CVS in a male infant who presented with generalized clonic cerebral seizures at age 4 months. An endogenous intracerebral viral reactivation following intrauterine VZV infection was assumed. After the diagnosis was confirmed virologically, acyclovir was administered intravenously for 10 days and afterwards orally for 3 weeks. This antiviral treatment was aimed at preventing progression of the disease. We concluded from this case that infants with intrauterine VZV infection can suffer intracerebral VZV reactivations that require antiviral treatment.
Authors:
A Sauerbrei; J Pawlak; C Luger; P Wutzler
Related Documents :
8933577 - Selective decontamination of the digestive tract: effect of cessation of routine applic...
21040197 - Twice-weekly fluconazole prophylaxis in premature infants: association with cholestasis.
11581437 - Enhanced urinalysis improves identification of febrile infants ages 60 days and younger...
9491087 - The history and physical assessments of the febrile infant.
8206417 - Annual birth patterns of savanna baboons (papio cynocephalus anubis) over a ten-year pe...
4095027 - Massive congenital mesenchymal malformation of the lung: a case report with ultrastruct...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  45     ISSN:  0012-1622     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-11     Completed Date:  2004-01-09     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  837-40     Citation Subset:  IM    
Affiliation:
Institute of Virology and Antiviral Therapy, Friedrich-Schiller University of Jena, Germany. Andreas.Sauerbrei@med.uni-jena.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Central Nervous System Diseases / drug therapy,  physiopathology,  virology
Chickenpox / diagnosis,  drug therapy,  physiopathology*,  virology
Electroencephalography
Female
Follow-Up Studies
Herpesvirus 3, Human*
Humans
Infant
Magnetic Resonance Imaging
Male
Polymerase Chain Reaction / methods
Pregnancy
Pregnancy Complications, Infectious / etiology*,  virology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Alternating hemiplegia of childhood: a syndrome inherited with an autosomal dominant trait.
Next Document:  Epilepsy and perisylvian polymicrogyria in a patient with Kabuki syndrome.