Document Detail


Intracerebral transplantation of genetically engineered cells for Parkinson's disease: toward clinical application.
MedLine Citation:
PMID:  17474294     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over the last decade, molecular biology has progressively developed, leading to new technology with subsequent clinical application for various cerebral diseases including Parkinson's disease (PD), one of the most investigated neurodegenerative disorders. The therapy for PD is mainly composed of medication, including drug replacement therapy, surgical treatment, and cell transplantation. Cell therapy for PD has been explored by using fetal nigral cells as an allo- or xenograft, autologous sympathetic ganglion, adrenal medulla, and carotid body in clinical settings. In addition, neurotrophic factors, including glial cell line-derived neurotrophic factor (GDNF), have a strong potency to rescue degenerating dopaminergic cells. Protein and/or gene therapy also might be a therapeutic option for PD. In this review, genetically engineered cell transplantation for animal models of PD, including catecholamine/neurotrophic factor-secreting cell transplantation with or without encapsulation, as performed in our laboratories, and their potential future as clinical applications are described with recent clinical studies in this field.
Authors:
Takao Yasuhara; Isao Date
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cell transplantation     Volume:  16     ISSN:  0963-6897     ISO Abbreviation:  Cell Transplant     Publication Date:  2007  
Date Detail:
Created Date:  2007-05-03     Completed Date:  2007-05-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208854     Medline TA:  Cell Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-32     Citation Subset:  IM    
Affiliation:
Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. tyasu37@cc.okayama-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Transplantation*
Dopamine / metabolism
Genetic Engineering*
Glial Cell Line-Derived Neurotrophic Factor / secretion
Humans
Parkinson Disease / genetics,  pathology*,  therapy*
Vascular Endothelial Growth Factor A / pharmacology
Chemical
Reg. No./Substance:
0/Glial Cell Line-Derived Neurotrophic Factor; 0/Vascular Endothelial Growth Factor A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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