Document Detail


Intracerebral synthesis of antibodies to measles and distemper viruses in patients with subacute sclerosing panencephalitis and multiple sclerosis.
MedLine Citation:
PMID:  7389198     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum and cerebrospinal fluid (CSF) measles and distemper antibody levels were quantified in a series of twenty patients (four subacute sclerosing panencephalitis (SSPE); ten multiple sclerosis (MS); six non-MS neurological cases) using independent competitive inhibition radioimmunoassays. These results were used in a Tourtellotte calculation to measure the intracerebral IgG synthesis to each virus. The results confirmed that in SSPE there is a greatly enhanced intracerebral measles antibody synthesis (6.0 mg/day). However, it was found that in SSPE this represents only part of a general systemic measles hyperimmunization as the intracerebral measles antibody synthesis relative to the total body measles synthesis was not significantly different from other groups (8%); In MS patients there was increased intracerebral immunoglobulin synthesis but the measles antibody levels were neither significantly elevated nor different from the control group. No evidence was found to support the concept that canine distemper virus is implicated in either MS or SSPE.
Authors:
N T Gorman; J Habicht; P J Lachmann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  39     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1980 Jan 
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  44-52     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Viral / biosynthesis*,  cerebrospinal fluid
Distemper Virus, Canine / immunology
Humans
Immunoglobulin G / biosynthesis,  cerebrospinal fluid
Measles virus / immunology
Multiple Sclerosis / immunology*
Subacute Sclerosing Panencephalitis / immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Immunoglobulin G
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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