Document Detail

Intracerebral hemorrhages associated with neurointerventional procedures using a combination of antithrombotic agents including abciximab.
MedLine Citation:
PMID:  12105375     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We report the occurrence of fatal intracerebral hemorrhage associated with using a combination of antithrombotic agents, including abciximab, in patients undergoing neurointerventional procedures.
SUMMARY OF REPORT: Seven patients (average age 60, range 46 to 73 years) developed fatal intracerebral hemorrhages associated with neurointerventional procedures and the use of intravenous abciximab. The procedures included angioplasty and stent placement in the cervical internal carotid artery (n=4), angioplasty of the intracranial internal carotid artery (n=1), and angioplasty of the middle cerebral artery (n=2). Clinical deterioration was observed within 1 hour of the procedure in 5 patients and 7 and 8 hours after the procedure, respectively, in the remaining 2 patients. All patients had received heparin and clopidogrel; 6 had also received aspirin.
CONCLUSIONS: Intracerebral hemorrhages can occur after neurointerventional procedures in patients with recent cerebral ischemic events, particularly when aggressive antithrombotic treatment is used.
Adnan I Qureshi; Mustafa Saad; Osama O Zaidat; Jose I Suarez; Michael J Alexander; M Fareed; K Suri; Zulfiqar Ali; L Nelson Hopkins
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  33     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-09     Completed Date:  2002-08-06     Revised Date:  2013-05-24    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1916-9     Citation Subset:  IM    
Department of Neurosurgery and Toshiba Stroke Research Center, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.
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MeSH Terms
Academic Medical Centers
Angioplasty* / adverse effects
Antibodies, Monoclonal / administration & dosage,  adverse effects*
Anticoagulants / administration & dosage
Carotid Artery Diseases / surgery
Cerebral Hemorrhage / chemically induced*,  diagnosis
Drug Therapy, Combination
Fatal Outcome
Fibrinolytic Agents / administration & dosage,  adverse effects*
Immunoglobulin Fab Fragments / administration & dosage,  adverse effects*
Infusions, Intravenous
Middle Aged
Middle Cerebral Artery / surgery
Neurosurgical Procedures* / adverse effects
Platelet Aggregation Inhibitors / administration & dosage
Tomography, X-Ray Computed
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Anticoagulants; 0/Fibrinolytic Agents; 0/Immunoglobulin Fab Fragments; 0/Platelet Aggregation Inhibitors; X85G7936GV/abciximab

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