Document Detail


Intracerebral haemorrhage in previously healthy adults following aerobic and anaerobic exercise.
MedLine Citation:
PMID:  12097223     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PRIMARY OBJECTIVE: Intracerebral haemorrhage (ICH) without demonstrated tissue pathology in previously healthy adults has not been previously linked to anaerobic or aerobic exercise. The possible mechanisms and risk factors for ICH that may be found in a young, "healthy" adult are described. RESEARCH DESIGN: Case reports of two patients who suffered a frontal lobe ICH following aerobic and anaerobic exercise are presented. A review of the literature was carried out to elucidate the risk factors for ICH in previously healthy adults. MAIN OUTCOMES: Hypocholesterolemia below 4.14 mmol/l, phenylpropanolamine use above 75 mg per day and certain apolipoprotein phenotypes (Apo E2 and Apo E4), which can all be found in young, healthy adults have all been described in the literature as contributors to the risk of ICH. CONCLUSIONS: There is a need for these risk factors to be researched in more detail, given that potential risk modifiers may help decrease their posed threat.
Authors:
Barry Cayen; Nora Cullen
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Brain injury : [BI]     Volume:  16     ISSN:  0269-9052     ISO Abbreviation:  Brain Inj     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-07-04     Completed Date:  2002-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8710358     Medline TA:  Brain Inj     Country:  England    
Other Details:
Languages:  eng     Pagination:  397-405     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Toronto, 550 University Avenue, Toronto, Ontario, M5G 2A2 Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Apolipoprotein E2
Apolipoprotein E4
Apolipoproteins E / genetics
Cerebral Hemorrhage / etiology*
Cerebral Ventricles / pathology
Cholesterol / blood
Dominance, Cerebral / physiology
Dose-Response Relationship, Drug
Exercise*
Frontal Lobe* / pathology
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Phenotype
Phenylpropanolamine / administration & dosage,  adverse effects
Risk Factors
Tomography, X-Ray Computed
Weight Lifting
Chemical
Reg. No./Substance:
0/Apolipoprotein E2; 0/Apolipoprotein E4; 0/Apolipoproteins E; 14838-15-4/Phenylpropanolamine; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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