Document Detail

Intracerebral haemorrhage associated with hourly concentration of ambient particulate matter: case-crossover analysis.
MedLine Citation:
PMID:  16847037     Owner:  NLM     Status:  MEDLINE    
AIMS: To examine the association of hourly time lagged concentration of ambient particulate matter and death due to stroke.
METHODS: Mortality data for five years (January 1990 to December 1994) were obtained from the Ministry of Health, Labour, and Welfare of Japan. Data were used only if the deceased was 65 years old or older at the time of death, if death was attributed to intracerebral haemorrhage or ischaemic stroke, and if the deceased lived in one of 13 major urban areas. Hourly mean concentrations of PM7, NO2, and photochemical oxidants were measured at monitoring stations in the 13 areas. Time stratified case-crossover analysis was used to examine the data for evidence of triggering stroke mortality.
RESULTS: The 1-hour mean concentration of PM7 measured about 2 hours before death was associated with the risk of death due to intracerebral haemorrhage from April to September (odds ratio = 2.40, 95% CI 1.48 to 3.89, for exposure to PM7 of more than 200 microg/m3 (threshold)). The higher risk was independent of the 24-hour mean concentration of PM7. PM7 was not associated with death due to ischaemic stroke.
CONCLUSIONS: Transiently high concentrations of PM7 are associated with death due to intracerebral haemorrhage. Air quality standards or guidelines for particulate matter should be based not only on 24-hour mean concentrations, but also on hourly data.
S Yamazaki; H Nitta; M Ono; J Green; S Fukuhara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-17
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  64     ISSN:  1470-7926     ISO Abbreviation:  Occup Environ Med     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-25     Completed Date:  2007-01-24     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  17-24     Citation Subset:  IM    
Department of Epidemiology and Healthcare Research, Graduate School of Public Health, Kyoto University, Kyoto, Japan.
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MeSH Terms
Air Pollutants / adverse effects*,  analysis
Cerebral Hemorrhage / etiology*,  mortality
Environmental Monitoring / methods
Epidemiologic Methods
Epidemiological Monitoring
Japan / epidemiology
Stroke / etiology*,  mortality
Time Factors
Urban Health / statistics & numerical data
Reg. No./Substance:
0/Air Pollutants
Comment In:
Occup Environ Med. 2007 Jan;64(1):3-4   [PMID:  17189452 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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