| Intracerebral dialysis monitoring of striatal dopamine release and metabolism in response to L-dopa. | |
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MedLine Citation:
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PMID: 2918307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have used intracerebral dialysis to monitor the striatal extracellular fluid (ECF) in rats with unilateral lesions of the nigrostriatal dopamine (DA) pathway. Dialysis samples were collected before and after L-dihydroxy-phenylalanine (L-DOPA) administration both in the presence and absence of carbidopa, an extracerebral DOPA decarboxylase (DDC) inhibitor. The baseline ECF levels of DA, 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) were always higher in the intact than in the lesioned striata. In the normal striata, dopamine (DA) concentrations increased following L-DOPA administration. Pretreatment with carbidopa prolonged the duration of the DA increase. In the lesioned striata, DA levels increased following L-DOPA administration only in animals pretreated with carbidopa. Following L-DOPA administration, striatal HVA and DOPAC levels increased considerably more in animals not pretreated with carbidopa than they did in pretreated animals. This increase was particularly marked in the lesioned striata and leads us to conclude that extracerebrally produced HVA and DOPAC can enter the brain extracellular space. |
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Authors:
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T Brannan; P Knott; H Kaufmann; L Leung; M Yahr |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of neural transmission Volume: 75 ISSN: 0300-9564 ISO Abbreviation: J. Neural Transm. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-04-04 Completed Date: 1989-04-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0337042 Medline TA: J Neural Transm Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 149-57 Citation Subset: IM |
Affiliation:
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Department of Neurology, Mount Sinai School of Medicine, New York, New York. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3,4-Dihydroxyphenylacetic Acid
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metabolism Animals Carbidopa / pharmacology* Corpus Striatum / drug effects, metabolism* Dialysis / methods* Dopamine / metabolism* Homovanillic Acid / metabolism Levodopa / pharmacology* Male Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
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NS-11631/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Levodopa; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 38821-49-7/Carbidopa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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