Document Detail


Intracellularly labeled pyramidal neurons in the cortical areas projecting to the spinal cord. I. Electrophysiological properties of pyramidal neurons.
MedLine Citation:
PMID:  15567476     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To study cortical motor control, we examined electrical characteristics of pyramidal neurons in the present report, and intra- or juxta-columnar connections of the pyramidal neurons to corticospinal neurons in the accompanying report. Pyramidal neurons were intracellularly recorded and stained in slices of rat motorsensory cortices (areas FL, HL and M1) where many corticospinal neurons were labeled retrogradely. They were morphologically classified into classical, star and other modified pyramidal neurons, and electrophysiologically into regular-spiking (RS), intrinsic bursting (IB) and irregular-spiking (IS) neurons on the basis of spiking pattern in response to 500 ms depolarizing current pulses. RS responses were further divided into RS with slow adaptation (RS-SA) and RS with fast adaptation (RS-FA). The electrical properties were associated with the laminar location of the neurons; RS-SA responses were observed frequently in layer II/III and less frequently in layers IV-VI, and IB and IS responses were exclusively found in layers V and VI, respectively. Interestingly, all layer IV neurons in area FL/HL were RS-FA star-pyramidal neurons, whereas layer IV neurons in area M1 were RS-SA classical pyramidal neurons. Although weak stimulation of areas FL/HL and M1 is known to elicit movement, these results suggest different information processings between the two areas.
Authors:
Ryong-Ho Cho; Satoko Segawa; Akio Mizuno; Takeshi Kaneko
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience research     Volume:  50     ISSN:  0168-0102     ISO Abbreviation:  Neurosci. Res.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-29     Completed Date:  2005-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8500749     Medline TA:  Neurosci Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  381-94     Citation Subset:  IM    
Affiliation:
Department of Developmental and Reconstructive Medicine, Division of Oral and Maxillofacial Surgery, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8102, Japan.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology*
Animals
Axons / physiology,  ultrastructure
Cell Shape / physiology
Dendrites / physiology,  ultrastructure
Dextrans
Immunohistochemistry
Lysine / analogs & derivatives*
Male
Microscopy, Fluorescence
Motor Cortex / cytology,  physiology*
Nerve Net / cytology,  physiology
Patch-Clamp Techniques
Pyramidal Cells / cytology,  physiology*
Pyramidal Tracts / cytology,  physiology*
Rats
Rats, Wistar
Rhodamines
Somatosensory Cortex / cytology,  physiology*
Synaptic Transmission / physiology
Chemical
Reg. No./Substance:
0/Fluoro-Ruby; 0/Rhodamines; 56-87-1/Lysine; 576-19-2/biocytin; 9004-54-0/Dextrans

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