Document Detail


Intracellular signaling specificity in skeletal muscle in response to different modes of exercise.
MedLine Citation:
PMID:  11299288     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to understand better the specific signaling events resulting from different modes of exercise. Three different exercise protocols were employed based on their well-characterized, long-term training effects on either muscle hypertrophy or endurance phenotypes. Rats were subjected to a single bout of either a high-frequency electrical stimulation, a low-frequency electrical stimulation, or a running exercise protocol. Postexercise intracellular signaling was analyzed in the tibialis anterior and soleus muscles at 0, 3, and 6 h. A prolonged increase in p70(S6k) and a transient increase in protein kinase B phosphorylation were only observed in response to a growth-inducing stimulus (e.g., tibialis anterior in high-frequency electrical stimulation). In contrast, extracellular regulated kinase and 38-kDa stress-activated protein kinase were activated in response to all forms of exercise at 0 h, but only extracellular regulated kinase phosphorylation was found significantly elevated at 6 h after running exercise. These results demonstrate that different exercise protocols resulted in the selective activation of specific intracellular signaling pathways, which may determine the specific adaptations induced by different forms of exercise.
Authors:
G A Nader; K A Esser
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  90     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-04-12     Completed Date:  2001-07-05     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1936-42     Citation Subset:  IM    
Affiliation:
Muscle Biology Laboratory, School of Kinesiology, The University of Illinois at Chicago, 60608, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Electric Stimulation
Female
MAP Kinase Signaling System / physiology*
Mitogen-Activated Protein Kinases / metabolism
Muscle Contraction / physiology
Muscle, Skeletal / physiology*
Phosphorylation
Physical Conditioning, Animal / physiology*
Physical Exertion / physiology*
Protein-Serine-Threonine Kinases*
Proto-Oncogene Proteins / metabolism
Proto-Oncogene Proteins c-akt
Rats
Rats, Wistar
Ribosomal Protein S6 Kinases / metabolism
Time Factors
p38 Mitogen-Activated Protein Kinases
Grant Support
ID/Acronym/Agency:
AR-45617/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 2.7.11.1/Ribosomal Protein S6 Kinases; EC 2.7.11.24/Mitogen-Activated Protein Kinases; EC 2.7.11.24/p38 Mitogen-Activated Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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