Document Detail

Intracellular redox state as determinant for melatonin antiproliferative vs cytotoxic effects in cancer cells.
MedLine Citation:
PMID:  21923620     Owner:  NLM     Status:  Publisher    
Abstract Melatonin is an endogenous indolamine classically known as a light/dark regulator. Besides classical functions, melatonin has also showed to have a wide range of antitumoral effects in numerous cancer experimental models. However, no definite mechanism has been described to explain the whole range of antineoplasic effects. Here we describe a dual effect of melatonin on intracellular redox state in relation to its antiproliferative vs cytotoxic actions in cancer cells. Thus, inhibition of proliferation correlates with a decrease on intracellular ROS and increase of antioxidant defenses (antioxidant enzymes and GSH levels), while induction of cell death correlates with an increase on intracellular ROS and decrease of antioxidant defenses. Moreover, cell death can be prevented by other well-known antioxidants or can be increased by hydrogen peroxide. Thus, tumor cell fate will depend on the ability of melatonin to induce either an antioxidant environment -related to the antiproliferative effect- or a prooxidant environment -related to the cytotoxic effect-.
Ana M Sánchez-Sánchez; Vanesa Martín; Guillermo García-Santos; Jezabel Rodríguez-Blanco; Sara Casado-Zapico; Santos Suarez-Garnacho; Isaac Antolín; Carmen Rodriguez
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-19
Journal Detail:
Title:  Free radical research     Volume:  -     ISSN:  1029-2470     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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