| Intracellular position of G2/M-phase nuclei in neoplastic and non-neoplastic pseudostratified glands suggests the occurrence of interkinetic nuclear migration. | |
| | |
MedLine Citation:
|
PMID: 23381606 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
It has been established that nuclear pseudostratification of the neural epithelium in vertebral embryos is caused by interkinetic nuclear migration, a cell cycle-dependent regulation of nuclear movement, during which the G2/M-phase nuclei move apically before returning basally in the G1/S phase. Here we demonstrate the cell cycle-related nuclear location characteristic of interkinetic nuclear migration in human neoplastic and non-neoplastic pseudostratified glands. Immunohistochemical analysis with phosphohistone H3 (a G2/M-phase marker) and Ki67 was performed on fetal tissues, proliferative-phase endometrium (5 cases), and colonic adenomas (12 cases). In all cases, G2/M nuclei were significantly located apically, whereas Ki67-positive nuclei were widely distributed along the basal-apical axis. In the proliferating zone of the normal colon mucosa, elongated nuclei in the G2/M phase were occasionally found on the apical side of the cells. These results suggest that the interkinetic nuclear migration occurs in association with cell proliferation in both neoplastic and non-neoplastic glands. |
| | |
Authors:
|
Takashi Kishimoto; Kazunori Fugo; Takako Kiyokawa |
Related Documents
:
|
21426866 - Efficient purification of neonatal porcine gonocytes with nycodenz and differential pla... 17822196 - Chloramphenicol: screening and review to evaluate its potential beneficial effects in l... 23143176 - Purification and visualization of encephalomyocarditisvirus synthesized by an in vitro ... 23692086 - Molecular mechanisms of lycoris aurea agglutinin-induced apoptosis and g2 /m cell cycle... 21426866 - Efficient purification of neonatal porcine gonocytes with nycodenz and differential pla... 19906106 - Ectopic expression of guanylyl cyclase c in gastric cancer as a potential biomarker and... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-2-5 |
Journal Detail:
|
Title: Medical molecular morphology Volume: - ISSN: 1860-1499 ISO Abbreviation: Med Mol Morphol Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-2-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101239023 Medline TA: Med Mol Morphol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Chiba University Graduate School of Medicine, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8670, Japan, tkishi@faculty.chiba-u.jp. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Humulone suppresses replication of respiratory syncytial virus and release of IL-8 and RANTES in nor...
Next Document: Micromonospora avicenniae sp. nov., isolated from a root of Avicennia marina.