Document Detail

Intracellular pH and bicarbonate concentration in human muscle during recovery from exercise.
MedLine Citation:
PMID:  29868     Owner:  NLM     Status:  MEDLINE    
Eight subjects exercised on an ergometer until exhaustion. Femoral venous blood was analyzed for lactate, pyruvate, protein, electrolytes, and acid-base parameters. Muscle samples taken during the recovery period from m. quadriceps femoris were analyzed for water, electrolytes, lactate, and acid-labile CO2. Water content in the muscle biopsy sample was increased after exercise to 78.7 +/- 0.5% compared with the normal 76.7 +/- 0.8% at rest. The distribution of water between the extra- and intracellular space was calculated by the chloride method. In spite of elevated PCO2 in femoral venous blood the content of acid-labile CO2 was decreased in muscle after exercise. One minute after termination of exercise muscle CO2 was about half of the normal content at rest. During the recovery period muscle CO2 increased but was 20 min after termination of exercise still significantly below the value at rest. Intracellular pH (pHi) and bicarbonate concentration ([HCO3-]i) in muscle have been calculated. The validity of the assumptions underlying the calculations are thoroughly discussed. pHi decreased from the normal value at rest, 7.00 +/- 0.06 (mean +/- SD), to about 6.4 after exercise. [HCO3-] decreased from 10.2 +/- 1.2 mmol/l at rest to about 3 mmol/l after exercise. The changes are the greatest so far reported for an in vivo situation. After 20 min recovery pHi was almost the same as at rest, whereas bicarbonate was still well below.
K Sahlin; A Alvestrand; R Brandt; E Hultman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  45     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1978 Sep 
Date Detail:
Created Date:  1978-12-20     Completed Date:  1978-12-20     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  474-80     Citation Subset:  IM; S    
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MeSH Terms
Acid-Base Equilibrium
Bicarbonates / metabolism*
Blood Proteins / metabolism
Body Water / metabolism
Carbon Dioxide / metabolism
Cell Compartmentation
Hydrogen-Ion Concentration*
Lactates / metabolism
Muscles / metabolism*
Physical Exertion*
Potassium / metabolism
Pyruvates / blood
Sodium / metabolism
Reg. No./Substance:
0/Bicarbonates; 0/Blood Proteins; 0/Lactates; 0/Pyruvates; 124-38-9/Carbon Dioxide; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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