Document Detail

Intracellular nucleotide pools and their significance in antimetabolite therapy.
MedLine Citation:
PMID:  6998365     Owner:  NLM     Status:  MEDLINE    
The regulatory properties of several ribo- and deoxyribonucleotides are outlined as a basis for a discussion of the modes of action of selected antimetabolites. Particular attention is devoted both to the perturbations induced by these agents in nucleotide pools and to the stability of endogenous pools as determinants of cytotoxicity. Attempts to modulate the activites of antimetabolites, either with specific nucleic acid presursors, or with other agents are discussed briefly.
K R Harrap; J Renshaw
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Antibiotics and chemotherapy     Volume:  28     ISSN:  0066-4758     ISO Abbreviation:  Antibiot Chemother (1971)     Publication Date:  1980  
Date Detail:
Created Date:  1980-11-20     Completed Date:  1980-11-20     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  1305576     Medline TA:  Antibiot Chemother (1971)     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  68-77     Citation Subset:  IM    
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MeSH Terms
3-Deazauridine / pharmacology
Antimetabolites, Antineoplastic / pharmacology*
Cell Cycle / drug effects
Coformycin / analogs & derivatives
Cytarabine / pharmacology
HeLa Cells
Leukemia L1210 / metabolism
Methotrexate / pharmacology
Nucleic Acids / biosynthesis*
Pyrimidine Nucleotides / biosynthesis*
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 0/Nucleic Acids; 0/Pyrimidine Nucleotides; 11033-22-0/Coformycin; 147-94-4/Cytarabine; 23205-42-7/3-Deazauridine; 59-05-2/Methotrexate

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