Document Detail

Intracellular localization of the HLA class II gene products in transfected mouse L cells.
MedLine Citation:
PMID:  1586968     Owner:  NLM     Status:  MEDLINE    
To investigate the impaired cell surface expression of human major histocompatibility antigen (HLA) in transfected L cells, we examined their intracellular localization by immunocytochemistry. HLA class II molecules produced in transfected L cells were mainly detected in the intracellular vesicles and in the nuclear envelope as granular precipitates. The results suggest that the intracellular transport of the newly synthesized molecules in transfected L cells is impaired at some point along the pathway from the rough endoplasmic reticulum (RER) to the medial-, trans-Golgi apparatus.
T Nakatsuji; A Akatsuka
Related Documents :
8707058 - Bacterial plasmid conjugation on semi-solid surfaces monitored with the green fluoresce...
18314198 - Single-cell electroporation of adult sensory neurons for gene screening with rna interf...
10357798 - Expression of stably transfected murine glutathione s-transferase a3-3 protects against...
1409618 - Translocation of apolipoprotein b across the endoplasmic reticulum is blocked in a nonh...
6147248 - Regulation of synthesis of citrate synthase in regreening euglena gracilis.
15188398 - Towards a standardized human proteome database: quantitative proteome profiling of livi...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell structure and function     Volume:  17     ISSN:  0386-7196     ISO Abbreviation:  Cell Struct. Funct.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-06-23     Completed Date:  1992-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608465     Medline TA:  Cell Struct Funct     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  55-60     Citation Subset:  IM    
Department of Transplantation, Tokai University School of Medicine, Isehara, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
B-Lymphocytes / immunology,  ultrastructure*
HLA-D Antigens / biosynthesis*,  genetics
HLA-DR Antigens / biosynthesis
L Cells (Cell Line) / immunology,  ultrastructure*
Organelles / immunology
Transfection / genetics
Reg. No./Substance:
0/HLA-D Antigens; 0/HLA-DR Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A method for accurate analysis of intermembrane space in organelles enclosed by double envelope memb...
Next Document:  Evidence for fluid-phase pinocytosis of extrahepatic bile duct cells isolated from normal rats in cu...