Document Detail


Intracellular localization of the HLA class II gene products in transfected mouse L cells.
MedLine Citation:
PMID:  1586968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the impaired cell surface expression of human major histocompatibility antigen (HLA) in transfected L cells, we examined their intracellular localization by immunocytochemistry. HLA class II molecules produced in transfected L cells were mainly detected in the intracellular vesicles and in the nuclear envelope as granular precipitates. The results suggest that the intracellular transport of the newly synthesized molecules in transfected L cells is impaired at some point along the pathway from the rough endoplasmic reticulum (RER) to the medial-, trans-Golgi apparatus.
Authors:
T Nakatsuji; A Akatsuka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell structure and function     Volume:  17     ISSN:  0386-7196     ISO Abbreviation:  Cell Struct. Funct.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-06-23     Completed Date:  1992-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608465     Medline TA:  Cell Struct Funct     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  55-60     Citation Subset:  IM    
Affiliation:
Department of Transplantation, Tokai University School of Medicine, Isehara, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
B-Lymphocytes / immunology,  ultrastructure*
HLA-D Antigens / biosynthesis*,  genetics
HLA-DR Antigens / biosynthesis
Immunohistochemistry
L Cells (Cell Line) / immunology,  ultrastructure*
Mice
Organelles / immunology
Transfection / genetics
Chemical
Reg. No./Substance:
0/HLA-D Antigens; 0/HLA-DR Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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