Document Detail

Intracellular lipid binding proteins and nuclear receptors involved in branched-chain fatty acid signaling.
MedLine Citation:
PMID:  12324226     Owner:  NLM     Status:  MEDLINE    
Branched-chain fatty acids are potent regulators of gene expression. Among them are the vitamin A-derived retinoic acids, which are involved in cell growth and differentiation, and the chlorophyll-derived phytol metabolites such as phytanic and pristanic acids, which affect catabolic lipid metabolism. Gene expression regulated by these signaling molecules is mediated by two protein families. These are, on the one hand, the intracellular lipid binding proteins, i.e. cellular retinoic acid binding protein and liver-type fatty acid binding protein, which are responsible for ligand-transport to the nucleus. On the other hand are the ligand-activated nuclear receptors, i.e. the retinoic acid receptors for retinoic acids and the peroxisome proliferator-activated receptors for the phytol metabolites. In this review, we discuss the cross-talk between the two protein families and how this cross-talk contributes to targeted signaling with branched-chain fatty acids.
A Adida; F Spener
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  67     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:    2002 Aug-Sep
Date Detail:
Created Date:  2002-09-26     Completed Date:  2003-09-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  91-8     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Ltd.
Department of Biochemistry, University of Münster, Münster, Germany.
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MeSH Terms
Fatty Acids / chemistry*,  metabolism*
Gene Expression Regulation
Lipid Metabolism*
Receptors, Cytoplasmic and Nuclear / metabolism*
Receptors, Retinoic Acid / metabolism
Signal Transduction*
Reg. No./Substance:
0/Fatty Acids; 0/Ligands; 0/Receptors, Cytoplasmic and Nuclear; 0/Receptors, Retinoic Acid

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