| Intracellular and intercellular processes determine robustness of the circadian clock. | |
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MedLine Citation:
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PMID: 21536033 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Circadian clocks are present in most organisms and provide an adaptive mechanism to coordinate physiology and behavior with predictable changes in the environment. Genetic, biochemical, and cellular experiments have identified more than a dozen component genes and a signal transduction pathway that support cell-autonomous, circadian clock function. One of the hallmarks of biological clocks is their ability to reset to relevant stimuli while ignoring most others. We review recent results showing intracellular and intercellular mechanisms that convey this robust timekeeping to a variety of circadian cell types. |
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Authors:
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John B Hogenesch; Erik D Herzog |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-04-28 |
Journal Detail:
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Title: FEBS letters Volume: 585 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-16 Completed Date: 2011-07-14 Revised Date: 2012-05-23 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1427-34 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. |
Affiliation:
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Department of Pharmacology, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. hogenesc@mail.med.upenn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Circadian Clocks* Circadian Rhythm Extracellular Space / metabolism* Intracellular Space / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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5R01HL 097800-04/HL/NHLBI NIH HHS; 5R01NS 054794-05/NS/NINDS NIH HHS; GM078993/GM/NIGMS NIH HHS; MH63104/MH/NIMH NIH HHS; R01 HL097800-02/HL/NHLBI NIH HHS; R01 HL097800-03/HL/NHLBI NIH HHS; R01 MH063104-10S1/MH/NIMH NIH HHS; R01 NS054794-04/NS/NINDS NIH HHS |
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