Document Detail

Intracellular hyperthermia for cancer using magnetite cationic liposomes: ex vivo study.
MedLine Citation:
PMID:  9310134     Owner:  NLM     Status:  MEDLINE    
Heating properties of magnetite cationic liposomes (MCL) were investigated in ex vivo experiments using implanted cell pellets. The cell pellets, which consisted of rat glioma T9 cells into which MCL had been incorporated in a petri dish, were implanted subcutaneously in the left femoral region of female F344 rats. The rats were placed in a magnetic field generating coil and irradiated with an alternating magnetic field (384 Oe, 118 kHz) for 60 min. The cell pellets were heated to over 43 degrees C by MCL in the magnetic field, but other body parts of the rats were not heated. After 3 cycles of magnetic heating, all glioma cells were killed and no tumor take was observed.
M Yanase; M Shinkai; H Honda; T Wakabayashi; J Yoshida; T Kobayashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese journal of cancer research : Gann     Volume:  88     ISSN:  0910-5050     ISO Abbreviation:  Jpn. J. Cancer Res.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-10-23     Completed Date:  1997-10-23     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8509412     Medline TA:  Jpn J Cancer Res     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  630-2     Citation Subset:  IM    
Department of Biotechnology, Graduate School of Engineering, Nagoya University.
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MeSH Terms
Ferrosoferric Oxide
Glioma / therapy*
Hyperthermia, Induced / methods*
Intracellular Fluid / metabolism
Iron / administration & dosage*
Neoplasm Transplantation
Oxides / administration & dosage*
Rats, Inbred F344
Reg. No./Substance:
0/Cations; 0/Liposomes; 0/Oxides; 1317-61-9/Ferrosoferric Oxide; 7439-89-6/Iron

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