| Intracellular hyperthermia for cancer using magnetite cationic liposomes: ex vivo study. | |
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MedLine Citation:
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PMID: 9310134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heating properties of magnetite cationic liposomes (MCL) were investigated in ex vivo experiments using implanted cell pellets. The cell pellets, which consisted of rat glioma T9 cells into which MCL had been incorporated in a petri dish, were implanted subcutaneously in the left femoral region of female F344 rats. The rats were placed in a magnetic field generating coil and irradiated with an alternating magnetic field (384 Oe, 118 kHz) for 60 min. The cell pellets were heated to over 43 degrees C by MCL in the magnetic field, but other body parts of the rats were not heated. After 3 cycles of magnetic heating, all glioma cells were killed and no tumor take was observed. |
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Authors:
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M Yanase; M Shinkai; H Honda; T Wakabayashi; J Yoshida; T Kobayashi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese journal of cancer research : Gann Volume: 88 ISSN: 0910-5050 ISO Abbreviation: Jpn. J. Cancer Res. Publication Date: 1997 Jul |
Date Detail:
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Created Date: 1997-10-23 Completed Date: 1997-10-23 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8509412 Medline TA: Jpn J Cancer Res Country: JAPAN |
Other Details:
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Languages: eng Pagination: 630-2 Citation Subset: IM |
Affiliation:
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Department of Biotechnology, Graduate School of Engineering, Nagoya University. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cations Female Ferrosoferric Oxide Glioma / therapy* Hyperthermia, Induced / methods* Intracellular Fluid / metabolism Iron / administration & dosage* Liposomes Neoplasm Transplantation Oxides / administration & dosage* Rats Rats, Inbred F344 |
| Chemical | |
Reg. No./Substance:
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0/Cations; 0/Liposomes; 0/Oxides; 1317-61-9/Ferrosoferric Oxide; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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