Document Detail


Intracellular hepatitis B virus nucleocapsids survive cytotoxic T-lymphocyte-induced apoptosis.
MedLine Citation:
PMID:  11000256     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Following antigen recognition, hepatitis B virus (HBV)-specific cytotoxic T lymphocytes (CTL) induce a necroinflammatory liver disease in HBV-transgenic mice. An early event in this process is CTL-dependent activation of apoptosis in a small fraction of HBV-positive hepatocytes. Here we show that cytoplasmic HBV nucleocapsids and their cargo of replicative DNA intermediates survive CTL-induced apoptosis of hepatocytes in vitro. These results suggest that destruction of infected cells per se is not sufficient to destroy the replicating HBV genome in infected tissue and that other events in addition to this process are required for viral clearance to occur.
Authors:
V Pasquetto; S Wieland; F V Chisari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of virology     Volume:  74     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-10-12     Completed Date:  2000-10-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9792-6     Citation Subset:  IM    
Affiliation:
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis*
DNA, Viral / metabolism
Hepatitis B Surface Antigens / immunology
Hepatitis B virus / immunology*
Liver / pathology*
Mice
Mice, Transgenic
Nucleocapsid / metabolism*
T-Lymphocytes, Cytotoxic / physiology*
Grant Support
ID/Acronym/Agency:
R37-CA40489/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Viral; 0/Hepatitis B Surface Antigens
Comments/Corrections

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