Document Detail

Intracellular free magnesium of brain and cerebral phosphorus-containing metabolites after subarachnoid hemorrhage and hypermagnesemic treatment: a ³¹P–magnetic resonance spectroscopy study. Clinical article.
MedLine Citation:
PMID:  19911890     Owner:  NLM     Status:  MEDLINE    
OBJECT: Disturbance of cerebral phosphorus-containing metabolites occurs in many disease entities and has not been widely studied in patients with subarachnoid hemorrhage (SAH). Pilot studies have indicated that hypermagnesemic treatment may improve outcome in patients with aneurysmal SAH, but the precise mechanism is not known. The authors hypothesized that, by raising intracellular brain free magnesium in aneurysmal SAH, hypermagnesemic treatment would alter the cerebral energy status. METHODS: The authors designed the current study to use ³¹P-MR spectroscopy (MRS) to investigate intracellular brain free magnesium and cerebral phosphorus-containing metabolites in patients with good-grade aneurysmal SAH, both those receiving and not receiving hypermagnesemic therapy. A total of 37 eligible patients and 23 healthy volunteers were recruited. A total of 81 MRS studies were performed. RESULTS: Hypermagnesemic treatment after aneurysmal SAH produced a small (mean difference 0.018 ± 0.007 mM [+ 13.0%]) but significant elevation of intracellular free magnesium during the 1st week. Aneurysmal SAH produced a depressed membrane metabolism with lower phosphodiester/total phosphate. CONCLUSIONS: The MRS finding of elevated brain free intracellular magnesium after intravenous magnesium sulfate infusion is novel, and the changes in membrane metabolism provide insight into the metabolic effects of aneurysmal SAH and future pathophysiological studies.
George K C Wong; David K W Yeung; Anil T Ahuja; Ann D King; Christopher W K Lam; Matthew T V Chan; Tony Gin; Wai S Poon
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  113     ISSN:  1933-0693     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  763-9     Citation Subset:  AIM; IM    
Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
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MeSH Terms
Brain Chemistry / drug effects*
Brain Ischemia / complications
Coma / etiology
Energy Metabolism / drug effects
Glasgow Coma Scale
Magnesium / blood,  metabolism*
Magnesium Compounds / pharmacokinetics,  therapeutic use*
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Middle Aged
Phosphorus / metabolism*
Phosphorus Isotopes
Subarachnoid Hemorrhage / metabolism*,  therapy*
Reg. No./Substance:
0/Magnesium Compounds; 0/Phosphorus Isotopes; 7439-95-4/Magnesium; 7723-14-0/Phosphorus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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