| Intracellular distribution of poliovirus proteins and the induction of virus-specific cytoplasmic structures. | |
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MedLine Citation:
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PMID: 6316654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a susceptible cell, enteroviruses induce a vesiculated region (the "virus-induced vesicles") which is both the site of viral RNA synthesis as well as the site referred to morphologically, as the "cytopathic effect." Proteins of poliovirus (type I, Mahoney) were shown to migrate into the region of the virus-induced vesicles of infected HEp-2 cells. Five proteins (P2-5b, P3-4b, P3-6a, P3-7c, P3-9) were found to be associated with the vesicles themselves, either as intrinsic membrane protein (P3-9) or in a soluble form within the vesicles (P3-4b, P3-7c, and, partially, P3-6a) or bound to a DOC-resistant structure (P2-5b and a small amount of P3-6a). Partial inhibition of the cleavage of the viral polyprotein with ZnCl2 was used to alter the viral protein pattern within the cells. The data obtained indicate that P2-5b is the protein responsible for the formation of the virus-induced vesicles. |
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Authors:
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K Bienz; D Egger; Y Rasser; W Bossart |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Virology Volume: 131 ISSN: 0042-6822 ISO Abbreviation: Virology Publication Date: 1983 Nov |
Date Detail:
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Created Date: 1984-01-27 Completed Date: 1984-01-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0110674 Medline TA: Virology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 39-48 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Hepatocellular Cell Line Cell Transformation, Viral* Cytoplasm / microbiology, ultrastructure Humans Kinetics Liver Neoplasms Microscopy, Electron Poliovirus / genetics*, ultrastructure Viral Proteins / genetics*, isolation & purification |
| Chemical | |
Reg. No./Substance:
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0/Viral Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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