| Intracellular cryptococci suppress Fc-mediated cyclin D1 elevation. | |
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MedLine Citation:
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PMID: 20798836 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Cryptococcus neoformans (Cn) is the only encapsulated fungal pathogen pathogenic to humans and macrophages play a vital role in the Cn infection pathway. Previously we documented that phagocytosis or crosslinking of FcgammaR on macrophage cell surface promoted macrophage cell cycle progression via the activation of MAPK pathway. However, we seldom observed sustained macrophage growth after they phagocytosed live Cn. In fact, many macrophages were finally observed to undergo apoptotic changes after phagocytosis of live Cn. Here we report that cyclin D1 elevation in macrophages promoted by phagocytosis was suppressed by intracellular Cn cells. This suggests a novel cytotoxic mechanism for host cells of intracellular cryptococci. |
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Authors:
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Yong Luo; Arturo Casadevall |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Communicative & integrative biology Volume: 3 ISSN: 1942-0889 ISO Abbreviation: Commun Integr Biol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-08-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101478473 Medline TA: Commun Integr Biol Country: United States |
Other Details:
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Languages: eng Pagination: 390-1 Citation Subset: - |
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