Document Detail


Intracellular antibodies: development and therapeutic potential.
MedLine Citation:
PMID:  7662306     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Single-chain antibodies, synthesized by the cell and targeted to a particular cellular compartment, can be used to interfere in a highly specific manner with cell growth and metabolism. Recent applications of this technology include the phenotypic knockout of growth-factor receptors, the functional inactivation of p21ras and the inhibition of HIV-1 replication. Intracellular antibodies are likely to have a widespread impact in biological research as a simple and effective alternative to other forms of gene inactivation; they demonstrate clear potential as reagents for cancer therapy and for the control of infectious diseases.
Authors:
J H Richardson; W A Marasco
Related Documents :
2421386 - Immunopathology associated with human lymphotropic retroviruses.
14645006 - Identification of circulating antigen-specific cd4+ t lymphocytes with a ccr5+, cytotox...
1350126 - Absence of selection of hiv-1 variants in vivo based on transcription/transactivation d...
17668896 - The th1 immune response against hiv-1 gag p24-derived peptides in mice expressing hla-a...
14653996 - Regulation of stem cell maintenance and transit amplifying cell proliferation by tgf-be...
7721346 - Class ii cytoplasmic and transmembrane domains are not required for class ii-mediated b...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Trends in biotechnology     Volume:  13     ISSN:  0167-7799     ISO Abbreviation:  Trends Biotechnol.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-10-06     Completed Date:  1995-10-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8310903     Medline TA:  Trends Biotechnol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  306-10     Citation Subset:  B; X    
Affiliation:
Division of Human Retrovirology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Antibodies / metabolism,  therapeutic use*
Biotechnology / trends
Drug Design
Humans
Intracellular Fluid / immunology
Molecular Sequence Data
Oligopeptides / chemistry,  metabolism
Oncogene Proteins / antagonists & inhibitors
Protein Sorting Signals*
Receptors, Growth Factor / metabolism
Virus Replication / immunology
Chemical
Reg. No./Substance:
0/Antibodies; 0/Oligopeptides; 0/Oncogene Proteins; 0/Protein Sorting Signals; 0/Receptors, Growth Factor; 113516-56-6/lysyl-aspartyl-glutamyl-leucine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical issues in antibody design.
Next Document:  High-pressure freeze fixation reveals novel features during ontogenesis of the vegetative cell in Le...