Document Detail

Intracellular antibodies: development and therapeutic potential.
MedLine Citation:
PMID:  7662306     Owner:  NLM     Status:  MEDLINE    
Single-chain antibodies, synthesized by the cell and targeted to a particular cellular compartment, can be used to interfere in a highly specific manner with cell growth and metabolism. Recent applications of this technology include the phenotypic knockout of growth-factor receptors, the functional inactivation of p21ras and the inhibition of HIV-1 replication. Intracellular antibodies are likely to have a widespread impact in biological research as a simple and effective alternative to other forms of gene inactivation; they demonstrate clear potential as reagents for cancer therapy and for the control of infectious diseases.
J H Richardson; W A Marasco
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Trends in biotechnology     Volume:  13     ISSN:  0167-7799     ISO Abbreviation:  Trends Biotechnol.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-10-06     Completed Date:  1995-10-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8310903     Medline TA:  Trends Biotechnol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  306-10     Citation Subset:  B; X    
Division of Human Retrovirology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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MeSH Terms
Amino Acid Sequence
Antibodies / metabolism,  therapeutic use*
Biotechnology / trends
Drug Design
Intracellular Fluid / immunology
Molecular Sequence Data
Oligopeptides / chemistry,  metabolism
Oncogene Proteins / antagonists & inhibitors
Protein Sorting Signals*
Receptors, Growth Factor / metabolism
Virus Replication / immunology
Reg. No./Substance:
0/Antibodies; 0/Oligopeptides; 0/Oncogene Proteins; 0/Protein Sorting Signals; 0/Receptors, Growth Factor; 113516-56-6/lysyl-aspartyl-glutamyl-leucine

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