Document Detail

Intracellular acid-base heterogeneity in nucleated avian erythrocytes.
MedLine Citation:
PMID:  8234     Owner:  NLM     Status:  MEDLINE    
1. Intracellular hydrogen ion activity, [H+]i, was extimated in human erythrocytes and in nucleated avian erythrocytes from measurements of the distribution of ammonia and 5,5'-dimethyloxazolidine-2,4'-dione (DMO) between intracellular and extracellular fluid. 2. In human erythrocytes there was no difference between values for [H+]i derived from measurements of either DMO or ammonia. 3. In avian erythrocytes, [H+]i(ammonia) was consistently greater than [H+]i(DMO), indicating significant acid-base heterogeneity of the intracellular water. The degree of heterogeneity was assessed by reference to a theoretical model of two compartments of equal size. 4. Experiments with nuclei isolated from avian erythrocytes suggested that DMO is not bound to nucleoproteins, and that the nucleus may be more acidic than the cytoplasm.
J M Bone; A Verth; A T Lambie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science and molecular medicine     Volume:  51     ISSN:  0301-0538     ISO Abbreviation:  Clin Sci Mol Med     Publication Date:  1976 Aug 
Date Detail:
Created Date:  1976-11-01     Completed Date:  1976-11-01     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  0367540     Medline TA:  Clin Sci Mol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  189-96     Citation Subset:  IM    
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MeSH Terms
Carbon Dioxide
Erythrocytes / physiology*
Hydrogen-Ion Concentration*
Models, Biological
Species Specificity
Reg. No./Substance:
124-38-9/Carbon Dioxide; 695-53-4/Dimethadione

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