| Intracellular acetyl unit transport in fungal carbon metabolism. | |
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MedLine Citation:
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PMID: 20889721 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acetyl coenzyme A (acetyl-CoA) is a central metabolite in carbon and energy metabolism. Because of its amphiphilic nature and bulkiness, acetyl-CoA cannot readily traverse biological membranes. In fungi, two systems for acetyl unit transport have been identified: a shuttle dependent on the carrier carnitine and a (peroxisomal) citrate synthase-dependent pathway. In the carnitine-dependent pathway, carnitine acetyltransferases exchange the CoA group of acetyl-CoA for carnitine, thereby forming acetyl-carnitine, which can be transported between subcellular compartments. Citrate synthase catalyzes the condensation of oxaloacetate and acetyl-CoA to form citrate that can be transported over the membrane. Since essential metabolic pathways such as fatty acid β-oxidation, the tricarboxylic acid (TCA) cycle, and the glyoxylate cycle are physically separated into different organelles, shuttling of acetyl units is essential for growth of fungal species on various carbon sources such as fatty acids, ethanol, acetate, or citrate. In this review we summarize the current knowledge on the different systems of acetyl transport that are operational during alternative carbon metabolism, with special focus on two fungal species: Saccharomyces cerevisiae and Candida albicans. |
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Authors:
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Karin Strijbis; Ben Distel |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-10-01 |
Journal Detail:
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Title: Eukaryotic cell Volume: 9 ISSN: 1535-9786 ISO Abbreviation: Eukaryotic Cell Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-03 Completed Date: 2011-03-10 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101130731 Medline TA: Eukaryot Cell Country: United States |
Other Details:
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Languages: eng Pagination: 1809-15 Citation Subset: IM |
Affiliation:
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Dept. of Medical Biochemistry, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, Netherlands. b.distel@amc.uva.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetyl Coenzyme A
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metabolism Acetyltransferases / genetics, metabolism* Candida albicans / enzymology*, genetics, metabolism Carbon / metabolism* Fungal Proteins / genetics, metabolism* Saccharomyces cerevisiae / enzymology*, genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Fungal Proteins; 72-89-9/Acetyl Coenzyme A; 7440-44-0/Carbon; EC 2.3.1.-/Acetyltransferases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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