| Intracellular Nucleic Acid Sensors and Autoimmunity. | |
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MedLine Citation:
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PMID: 22029446 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A collection of molecular sensors has been defined by studies in the last decade that can recognize a diverse array of pathogens and initiate protective immune and inflammatory responses. However, if the molecular signatures recognized are shared by both foreign and self-molecules, as is the case of nucleic acids, then the responses initiated by these sensors may have deleterious consequences. Notably, this adverse occurrence may be of primary importance in autoimmune disease pathogenesis. In this case, microbe-induced damage or mishandled physiologic processes could lead to the generation of microparticles containing self-nucleic acids. These particles may inappropriately gain access to the cytosol or endolysosomes and, hence, engage resident RNA and DNA sensors. Evidence, as reviewed here, strongly indicates that these sensors are primary contributors to autoimmune disease pathogenesis, spearheading efforts toward development of novel therapeutics for these disorders. |
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Authors:
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Argyrios N Theofilopoulos; Dwight H Kono; Bruce Beutler; Roberto Baccala |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-27 |
Journal Detail:
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Title: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research Volume: - ISSN: 1557-7465 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9507088 Medline TA: J Interferon Cytokine Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Immunology and Microbial Science, The Scripps Research Institute , La Jolla, California. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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