Document Detail


Intracellular BK(Ca) (iBK(Ca)) channels.
MedLine Citation:
PMID:  22930268     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The large conductance calcium- and voltage-activated potassium channel (BK(Ca)) is widely expressed at the plasma membrane. This channel is involved in a variety of fundamental cellular functions including excitability, smooth muscle contractility, and Ca(2+) homeostasis, as well as in pathological situations like proinflammatory responses in rheumatoid arthritis, and cancer cell proliferation. Immunochemical, biochemical and pharmacological studies from over a decade have intermittently shown the presence of BK(Ca) in intracellular organelles. To date, intracellular BK(Ca) (iBK(Ca)) has been localized in the mitochondria, endoplasmic reticulum, nucleus and Golgi apparatus but its functional role remains largely unknown except for the mitochondrial BK(Ca) whose opening is thought to play a role in protecting the heart from ischaemic injury. In the nucleus, pharmacology suggests a role in regulating nuclear Ca(2+), membrane potential and eNOS expression. Establishing the molecular correlates of iBK(Ca), the mechanisms defining iBK(Ca) organelle-specific targeting, and their modulation are challenging questions. This review summarizes iBK(Ca) channels, their possible functions, and efforts to identify their molecular correlates.
Authors:
Harpreet Singh; Enrico Stefani; Ligia Toro
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-08-28
Journal Detail:
Title:  The Journal of physiology     Volume:  590     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-05-17     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  5937-47     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Large-Conductance Calcium-Activated Potassium Channels / physiology*
Organelles / physiology
Grant Support
ID/Acronym/Agency:
HL088640/HL/NHLBI NIH HHS; HL096740/HL/NHLBI NIH HHS; HL107418/HL/NHLBI NIH HHS; R01 HL107418/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Large-Conductance Calcium-Activated Potassium Channels
Comments/Corrections

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