Document Detail

Intracavitary amphotereicin B in the treatment of symptomatic pulmonary aspergillomas.
MedLine Citation:
PMID:  7361807     Owner:  NLM     Status:  MEDLINE    
The optimal treatment of pulmonary aspergillomas is not established. Surgical resection is often impossible because of severe, underlying pulmonary impairment, and medical treatment has given negative or inconclusive results. Six patients with symptomatic pulmonary aspergillomas were treated with percutaneous instillation of intracavitary amphotericin B. Four patients who received the full course of therapy showed improvement and stabilization or reversal of progressive roentgenographic changes. Also, follow-up serologic studies of Aspergillus spp. precipitins were obtained in three and were negative. One patient did not tolerate this treatment because of repeated systemic reactions. Another patient did not respond clinically or roentgenographically. Intracavitary amphotericin B therapy should be considered in patients with symptomatic pulmonary aspergilloma, particularly when surgical resection is not feasible.
J L Hargis; R C Bone; J Stewart; N Rector; F C Hiller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  68     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1980 Mar 
Date Detail:
Created Date:  1980-05-23     Completed Date:  1980-05-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  389-94     Citation Subset:  AIM; IM    
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MeSH Terms
Amphotericin B / administration & dosage*,  adverse effects
Aspergillosis, Allergic Bronchopulmonary / drug therapy*,  radiography,  surgery
Middle Aged
Reg. No./Substance:
1397-89-3/Amphotericin B

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