Document Detail

Intracavernous injection of papaverine as a diagnostic and therapeutic method in erectile failure.
MedLine Citation:
PMID:  6696289     Owner:  NLM     Status:  MEDLINE    
The effect of intracavernous injection of papaverine (ICIP) has been investigated in 45 men: 6 normally potent volunteers, 10 psychogenic, and 29 organic impotent males. The first two groups obtained erections within 10 minutes, lasting from 1 to 4 hours, after injection of 80 mg of papaverine. Those belonging to the organic group experienced delayed, weaker and shorter erections, related to various degrees of arterial and/or venous and neurologic lesions. Haemodynamic and radiologic studies done concomitantly, showed a strong vasodilation in the penile arteries (even when pathologic) and a diminished outflow from the cavernous bodies. Subsequently, a pilot study was performed in a series of 63 patients suffering from various degrees of angiogenic impotence, in order to study the therapeutic effect of repeated intracavernous injections of papaverine completed by intracavernous infusion of heparinized saline. Erections improved significantly in 66% of the patients with a mean follow up of one year.
R Virag; D Frydman; M Legman; H Virag
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Angiology     Volume:  35     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-03-23     Completed Date:  1984-03-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  79-87     Citation Subset:  IM    
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MeSH Terms
Arterial Occlusive Diseases / physiopathology
Blood Pressure / drug effects
Diabetic Angiopathies / physiopathology
Erectile Dysfunction / drug therapy,  physiopathology,  radiography*
Follow-Up Studies
Middle Aged
Papaverine / administration & dosage*,  therapeutic use
Penis / blood supply,  drug effects*
Vasodilator Agents / administration & dosage*,  therapeutic use
Reg. No./Substance:
0/Vasodilator Agents; 58-74-2/Papaverine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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