Document Detail


Intracavernosal administration of sodium nitrite as an erectile pharmacotherapy.
MedLine Citation:
PMID:  20651825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been reported that sodium nitrite (NaNO2) can act as a storage form of nitric oxide (NO) that can have beneficial pharmacologic actions. The present study was undertaken to investigate the effects of NaNO2 on erectile function in the rat. The intracavernosal (i.c.) injection of NaNO2 produced dose-related increases in i.c. pressure and decreases in systemic arterial pressure. NaNO2 was 1000-fold less potent than sodium nitroprusside in increasing i.c. pressure. Increases in i.c. pressure in response to NaNO2 were attenuated by the nitric oxide synthase (NOS) inhibitor N-nitro-L-arginine methyl ester (L-NAME). The increases in i.c. pressure in response to NaNO2 were not altered by the xanthine oxidoreductase inhibitor allopurinol. The decreases in systemic arterial pressure in response to i.c. injections of NaNO2 were attenuated by allopurinol and were either unchanged or increased by L-NAME. These data suggest that NaNO2 is converted to vasoactive NO in the corpora cavernosum and systemic vascular bed of the rat by different mechanisms. The present data suggest that the conversion of NaNO2 to vasoactive NO is mediated by NOS in the corpora cavernosum and by xanthine oxidoreductase in the systemic vascular bed of the rat. These data show NaNO2 can serve as a NO donor that increases erectile activity in the rat.
Authors:
George F Lasker; Christopher J Matt; Adeleke M Badejo; David B Casey; Jasdeep S Dhaliwal; Subramanyam N Murthy; Philip J Kadowitz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  88     ISSN:  1205-7541     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-23     Completed Date:  2010-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  770-6     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Tulane University Medical Center, 1430 Tulane Avenue, SL83, New Orleans, LA 70112-2699, USA.
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MeSH Terms
Descriptor/Qualifier:
Allopurinol / administration & dosage
Animals
Blood Pressure / drug effects
Enzyme Inhibitors / administration & dosage
Erectile Dysfunction / drug therapy*,  physiopathology
Male
NG-Nitroarginine Methyl Ester / administration & dosage
Nitric Oxide Donors / administration & dosage
Nitric Oxide Synthase / antagonists & inhibitors
Nitroprusside / administration & dosage
Penile Erection / drug effects*,  physiology
Penis / blood supply,  drug effects,  physiology
Rats
Rats, Sprague-Dawley
Sodium Nitrite / administration & dosage*
Vasodilator Agents / administration & dosage
Grant Support
ID/Acronym/Agency:
HL-62000/HL/NHLBI NIH HHS; HL-77412/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Nitric Oxide Donors; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 315-30-0/Allopurinol; 50903-99-6/NG-Nitroarginine Methyl Ester; 7632-00-0/Sodium Nitrite; EC 1.14.13.39/Nitric Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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