Document Detail

Intracarotid slow bolus injection of nimodipine during angiography for treatment of cerebral vasospasm after SAH. A preliminary report.
MedLine Citation:
PMID:  6737047     Owner:  NLM     Status:  MEDLINE    
Nimodipine was given as an intracarotid slow bolus injection in six patients with subarachnoid hemorrhage (SAH) due to rupture of a cerebral aneurysm, with angiographically demonstrated vasospasm. The patients were followed by serial angiograms for demonstration of the effect of nimodipine on vasospasm. After angiography, all patients were treated with a constant venous infusion of this new calcium antagonist. Although the therapeutic regimen was started only a few hours after onset of vasospasm, there was no change in cerebral vessel caliber detectable on angiograms following the intracarotid injection. Three patients died, two patients finally recovered with neurological deficits due to cerebral ischemia, and one patient with asymptomatic vasospasm remained symptom-free. Although nimodipine may act to prevent cerebral vasospasm after SAH, the authors believe that the intracarotid application is not effective after vasospasm has occurred.
J A Grotenhuis; W Bettag; B J Fiebach; K Dabir
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  61     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-08-23     Completed Date:  1984-08-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  231-40     Citation Subset:  AIM; IM    
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MeSH Terms
Carotid Arteries
Cerebral Angiography
Injections, Intra-Arterial
Ischemic Attack, Transient / complications,  drug therapy*,  radiography
Middle Aged
Nicotinic Acids / administration & dosage*
Subarachnoid Hemorrhage / complications,  drug therapy*,  radiography
Reg. No./Substance:
0/Nicotinic Acids; 66085-59-4/Nimodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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