Document Detail


Intracarotid hydroxyethyl methacrylate solution causing stroke in dogs.
MedLine Citation:
PMID:  2213166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hydroxyethyl methacrylate (HEMA) has been advocated as a polymerizing solution with which to prevent deflation of detachable balloons in interventional neuroradiology. It is pertinent to know if unpolymerized HEMA would have untoward effects if accidentally released into the carotid artery by balloon rupture or deflation. Seven mongrel dogs underwent transfemoral catheterization of the common carotid artery and subsequent injection of HEMA solution in volumes of 1 cc in five dogs, 2 cc in one, and 4 cc in one. Angiography performed at the time of injection revealed evidence of intravascular thrombosis as well as possible spasm. Three surviving animals were sacrificed at 48 hours; the brains were fixed and examined histopathologically. One brain was normal and one was autolyzed and could not be examined. Five of the seven animals had histopathologically documented cerebral infarctions of varying size. No foreign substance was seen within the blood vessels to suggest intravascular polymerization. The animals injected with 2 or 4 cc HEMA solution did not survive 48 hours. Literature review reveals little documentation of the toxicology of intravascular HEMA. With its increasing popularity as a compound for polymerization in detachable balloons introduced into the brain, further investigations are warranted to understand the physical properties of the compound and potential risks of its use.
Authors:
P Purdy; C L White; H Batjer; K Brewer; K Hodges; D Samson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  73     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1990-11-21     Completed Date:  1990-11-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  756-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Radiology, University of Texas Southwestern Medical Center, Dallas.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carotid Arteries
Cerebral Angiography
Cerebrovascular Disorders / chemically induced*
Dogs
Embolization, Therapeutic
Injections, Intra-Arterial
Methacrylates / adverse effects*
Chemical
Reg. No./Substance:
0/Methacrylates; 868-77-9/hydroxyethyl methacrylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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